Abstract | INTRODUCTION: AREAS COVERED: Recent studies showing successful pharmacologic treatment of proliferative DR will probably lead to increased use of pharmacotherapy, thereby further emphasizing the need for longer duration drugs. Recently approved anti- VEGF drugs ( aflibercept) and corticosteroids ( dexamethasone and fluocinolone inserts) provide extended durations of action. Longer action anti- VEGF molecules, sustained release devices and pumps, and encapsulated cell technology, may further decrease treatment burden, though regulatory approval may not occur for at least 5 years. Oral medications ( danazol and minocycline) and modified topical drugs ( loteprednol) will require daily administration but may decrease the frequency of visits to physicians' offices. Intravitreally administered drugs that target different biochemical pathways are being developed as monotherapy and combination therapy, and their effects on durability remains to be seen. EXPERT OPINION: The rich development pipeline promises to provide improved therapeutic options in addition to drugs and devices with longer duration of action.
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Authors | Michael W Stewart, Harry W Flynn Jr, Stephen G Schwartz, Ingrid U Scott |
Journal | Expert opinion on drug delivery
(Expert Opin Drug Deliv)
Vol. 13
Issue 9
Pg. 1277-87
(09 2016)
ISSN: 1744-7593 [Electronic] England |
PMID | 27293138
(Publication Type: Journal Article, Review)
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Chemical References |
- Glucocorticoids
- Recombinant Fusion Proteins
- Vascular Endothelial Growth Factor A
- Fluocinolone Acetonide
- aflibercept
- fluocinolone
- Receptors, Vascular Endothelial Growth Factor
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Topics |
- Diabetic Retinopathy
(drug therapy)
- Fluocinolone Acetonide
(administration & dosage, analogs & derivatives)
- Glucocorticoids
(administration & dosage)
- Humans
- Intravitreal Injections
- Macular Edema
(drug therapy)
- Receptors, Vascular Endothelial Growth Factor
(administration & dosage)
- Recombinant Fusion Proteins
(administration & dosage)
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
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