Abstract | PURPOSE: METHODS: The number of lymphocytes and NK cells, and NK cell activity, were assessed using flow cytometry and a (51)Cr release assay, respectively. RESULTS: A total of 26 patients with untreated ATL or PTCL were enrolled, and blood samples from 25 patients were evaluable. NK cell number in ATL decreased after mLSG15/-L treatment, and the degree of decrease in the NK cell number was more prominent just before VECP therapy (Day 15-17 of each cycle) than just before VCAP therapy (Day 1 of each cycle). The NK cell number in ATL after CHOP/-L treatment also decreased. Interestingly, the NK cell activity showed a tendency to increase after the treatment. NK cell number in PTCL did not decrease by CHOP/-L regimen, but the activity was slightly decreased after the treatment. CONCLUSIONS: These results indicate that the effects of chemotherapeutic agents on NK cells vary according to the disease type and intensity of chemotherapy.
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Authors | Michinori Ogura, Takashi Ishida, Kunihiro Tsukasaki, Takeshi Takahashi, Atae Utsunomiya |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 78
Issue 1
Pg. 199-207
(Jul 2016)
ISSN: 1432-0843 [Electronic] Germany |
PMID | 27289375
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Nitrosourea Compounds
- Vincristine
- Etoposide
- Doxorubicin
- Cyclophosphamide
- Carboplatin
- Vindesine
- ranimustine
- Prednisone
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, pharmacology, therapeutic use)
- Carboplatin
(administration & dosage)
- Case-Control Studies
- Cyclophosphamide
(administration & dosage, pharmacology, therapeutic use)
- Doxorubicin
(administration & dosage, pharmacology, therapeutic use)
- Etoposide
(administration & dosage)
- Female
- Flow Cytometry
- Humans
- Killer Cells, Natural
(drug effects, metabolism)
- Leukemia-Lymphoma, Adult T-Cell
(drug therapy, pathology)
- Lymphoma, T-Cell, Peripheral
(drug therapy, pathology)
- Male
- Middle Aged
- Nitrosourea Compounds
(administration & dosage)
- Prednisone
(administration & dosage, pharmacology, therapeutic use)
- Vincristine
(administration & dosage, pharmacology, therapeutic use)
- Vindesine
(administration & dosage)
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