Abstract | BACKGROUND:
CYP2B6 polymorphisms contribute to inter-individual variations in pharmacokinetics of methadone. Increased pain sensitivity is frequently reported by opioid dependent patients on methadone maintenance therapy ( MMT). It is possible, therefore, that genetic polymorphisms in CYP2B6, which affects the metabolism of methadone, influence pain sensitivity among patients on MMT. This study investigated CYP2B6 polymorphisms and pain sensitivity in this group. METHODS: The cold pressor pain responses of 148 opioid dependent patients receiving MMT were evaluated using the cold pressor test ( CPT). DNA was extracted from whole blood and subjected to polymerase chain reaction (PCR)-genotyping. RESULTS: Of the 148 subjects, 77 (52.0%) were carriers of CYP2B6*6 allele. CYP2B6*6 allele carriers had shorter cold pain threshold and pain tolerance times than non-carriers of CYP2B6*6 allele (21.05s vs 33.69s, p=0.036 and 27.15s vs 44.51s, p=0.020, respectively). Pain intensity scores of the CYP2B6*6 allele carriers was 67.55, whereas that of the CYP2B6*6 allele non-carriers was 64.86 (p=0.352). CONCLUSION: Our study indicates that the CYP2B6*6 allele is associated with a lower pain threshold and lower pain tolerance among males with opioid dependence on MMT. The CYP2B6*6 allele may provide a mechanistic explanation for clinical observations of heightened pain sensitivity among opioid dependent patients receiving MMT.
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Authors | Zalina Zahari, Chee Siong Lee, Muslih Abdulkarim Ibrahim, Nurfadhlina Musa, Mohd Azhar Mohd Yasin, Yeong Yeh Lee, Soo Choon Tan, Nasir Mohamad, Rusli Ismail |
Journal | Drug and alcohol dependence
(Drug Alcohol Depend)
Vol. 165
Pg. 143-50
(Aug 01 2016)
ISSN: 1879-0046 [Electronic] Ireland |
PMID | 27289271
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Analgesics, Opioid
- Cytochrome P-450 CYP2B6
- Methadone
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Topics |
- Adult
- Alleles
- Analgesics, Opioid
(therapeutic use)
- Cytochrome P-450 CYP2B6
(genetics)
- Genotype
- Heterozygote
- Humans
- Male
- Methadone
(blood, pharmacokinetics, therapeutic use)
- Opiate Substitution Treatment
- Opioid-Related Disorders
(drug therapy)
- Pain
(drug therapy, genetics)
- Pain Threshold
(drug effects)
- Polymorphism, Genetic
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