Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: C57BL/6 mice were subjected to chronic constriction injury (CCI) of the sciatic nerve. The effects of systemic administration of morphine and the pan- cannabinoid receptor agonist, WIN55212, on allodynia and side effects were examined at 7-10 days post-CCI surgery. Isobolographic analysis was used to determine whether the effects of the combination were synergistic. KEY RESULTS: CONCLUSIONS AND IMPLICATIONS: These findings indicate that administration of a combination of a non-selective opioid and cannabinoid receptor agonist synergistically reduces nerve injury-induced allodynia, while producing side effects in an additive manner. This suggests that this combination treatment has an improved anti-allodynic potency and therapeutic index in a neuropathic pain model.
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Authors | Nicholas P Kazantzis, Sherelle L Casey, Patrick W Seow, Vanessa A Mitchell, Christopher W Vaughan |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 173
Issue 16
Pg. 2521-31
(08 2016)
ISSN: 1476-5381 [Electronic] England |
PMID | 27278681
(Publication Type: Journal Article)
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Copyright | © 2016 The British Pharmacological Society. |
Chemical References |
- Analgesics, Opioid
- Cannabinoids
- Morphine
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Topics |
- Analgesics, Opioid
(antagonists & inhibitors, therapeutic use)
- Animals
- Cannabinoids
(therapeutic use)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Synergism
- Male
- Mice
- Mice, Inbred C57BL
- Morphine
(administration & dosage, pharmacology)
- Neuralgia
(drug therapy, surgery)
- Structure-Activity Relationship
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