Abstract | BACKGROUND:
Bisphenol A (BPA) exposure has been associated with increased incidence of diabetes and obesity in adults. OBJECTIVES: To evaluate whether an association between BPA urinary levels and insulin resistance as well as adiponectin and resistin production and serum concentrations may occur in obese children. METHODS: Clinical and biochemical features of 141 obese children were collected. Serum resistin and adiponectin were evaluated. Insulin resistance and urinary BPA levels were assessed. Moreover, the effect of BPA on adiponectin and resistin gene expression in adipocytes from eight normal weight prepubertal children was investigated by quantitative real-time RT-PCR (qPCR). RESULTS: Direct association between BPA and homeostasis model assessment (r = 0.23; p: 0.0069) and a strong inverse association between BPA and adiponectin have been found (r = -0.48; p < 0.0001). In adipocytes, resistin expression was detected only after BPA treatment, while adiponectin expression resulted down-regulated after BPA exposure (p < 0.05 at both 10 and 100 nM BPA concentrations). CONCLUSIONS:
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Authors | Ciro Menale, Anna Grandone, Carla Nicolucci, Grazia Cirillo, Stefania Crispi, Anna Di Sessa, Pierluigi Marzuillo, Sergio Rossi, Damiano Gustavo Mita, Laura Perrone, Nadia Diano, Emanuele Miraglia Del Giudice |
Journal | Pediatric obesity
(Pediatr Obes)
Vol. 12
Issue 5
Pg. 380-387
(10 2017)
ISSN: 2047-6310 [Electronic] England |
PMID | 27187765
(Publication Type: Journal Article, Observational Study)
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Copyright | © 2016 World Obesity Federation. |
Chemical References |
- ADIPOQ protein, human
- Adiponectin
- Benzhydryl Compounds
- Phenols
- RETN protein, human
- Resistin
- bisphenol A
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Topics |
- Adiponectin
(metabolism)
- Adipose Tissue
(metabolism)
- Adolescent
- Benzhydryl Compounds
(adverse effects, urine)
- Child
- Cross-Sectional Studies
- Female
- Gene Expression
- Humans
- Insulin Resistance
(genetics)
- Male
- Pediatric Obesity
(genetics)
- Phenols
(adverse effects, urine)
- Real-Time Polymerase Chain Reaction
- Resistin
(metabolism)
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