Abstract | BACKGROUND: OBJECTIVE: STUDY DESIGN: This was a retrospective cohort study of patients with complete hydatidiform mole who were diagnosed, treated, and followed at the Center of Trophoblastic Diseases (Botucatu/São Paulo State and Rio de Janeiro/Rio de Janeiro State, Brazil) from 1995-2014. Patients were divided temporally into derivation (1995-2004) and validation (2005-2014) cohorts. Immunohistochemistry was used to examine tissue expression of the apoptosis inhibitor survivin or the pro-apoptotic enzyme caspase-3. Survivin stains for cytoplasmic and nuclear expression were evaluated independently. Caspase-3 expression was measured as an apoptotic index of positive staining cells over negative staining cells multiplied by 100. Receiver operating characteristic curves were then constructed, and the area under the curve was calculated to test the performance characteristics of the staining to predict the subsequent development of gestational trophoblastic neoplasia. RESULTS: CONCLUSION:
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Authors | Antonio Braga, Izildinha Maestá, Renan Rocha Soares, Kevin M Elias, Maria Aparecida Custódio Domingues, Luis Fernando Barbisan, Ross S Berkowitz |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 215
Issue 3
Pg. 336.e1-336.e12
(09 2016)
ISSN: 1097-6868 [Electronic] United States |
PMID | 27094961
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Chemical References |
- BIRC5 protein, human
- Biomarkers
- Inhibitor of Apoptosis Proteins
- Survivin
- Caspase 3
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Topics |
- Adult
- Apoptosis
- Biomarkers
(metabolism)
- Caspase 3
(metabolism)
- Cohort Studies
- Female
- Gestational Trophoblastic Disease
(pathology)
- Humans
- Hydatidiform Mole
(pathology)
- Immunohistochemistry
- Inhibitor of Apoptosis Proteins
(metabolism)
- Predictive Value of Tests
- Pregnancy
- Risk Factors
- Sensitivity and Specificity
- Survivin
- Trophoblasts
(metabolism, pathology)
- Uterine Neoplasms
(pathology)
- Young Adult
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