Abstract | BACKGROUND: In the previous study, active extract of Radix Scrophularia (ACRS) demonstrated beneficial effects on ventricular remodeling induced by coronary artery ligation and lowered blood pressure in rats. And ACRS also exhibited the effect on lowering the blood pressure in spontaneously hypertensive rats (SHRs). The aim of this study is to explore the effects of ACRS on ventricular remodeling in SHRs and underlying mechanisms. RESULTS: CONCLUSION: Continuous treatment of SHRs with ACRS for 21 weeks reduced blood pressure, myocardial hypertrophy and the amount of interstitial and perivascular collagen, which indicated that ACRS could prevent hypertensive ventricular remodeling. This can be attributed to suppression of the sympathetic nervous and renin angiotensin aldosterone system through the inhibition of ERK 1/2, JNK and p38 MAPK pathways.
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Authors | Chao Chao Zhang, Wei Liang Gu, Xi Min Wu, Yi Ming Li, Chang Xun Chen, Xiao Yan Huang |
Journal | SpringerPlus
(Springerplus)
Vol. 5
Pg. 358
( 2016)
ISSN: 2193-1801 [Print] Switzerland |
PMID | 27066371
(Publication Type: Journal Article)
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