Do advanced glycation end-products play a role in malaria susceptibility?

Abstract	There are growing data supporting the differences in susceptibility to malaria described between sympatric populations with different lifestyles. Evidence has also been growing for some time that nutritional status and the host's metabolism are part of the complex mechanisms underlying these differences. The role of dietary advanced glycation end-products (AGEs) in the modulation of immune responses (innate and adaptive responses) and chronic oxidative stress has been established. But less is known about AGE implication in naturally acquired immunity and susceptibility to malaria. Since inflammatory immune responses and oxidative events have been demonstrated as the hallmark of malaria infection, it seems crucial to investigate the role of AGE in susceptibility or resistance to malaria. This review provides new insight into the relationship between nutrition, metabolic disorders, and infections, and how this may influence the mechanisms of susceptibility or resistance to malaria in endemic areas.
Authors	Karim Traoré, Charles Arama, Maurice Médebielle, Ogobara Doumbo, Stéphane Picot
Journal	Parasite (Paris, France) (Parasite) Vol. 23 Pg. 15 ( 2016) ISSN: 1776-1042 [Electronic] France
PMID	27012162 (Publication Type: Journal Article, Review)
Copyright	© K. Traoré et al., published by EDP Sciences, 2016.
Chemical References	AGER protein, human Glycation End Products, Advanced HMGB1 Protein HMGB1 protein, human Receptor for Advanced Glycation End Products
Topics	Chromosomes, Human, Pair 6 (genetics) Cooking Diet (adverse effects) Disease Susceptibility Endemic Diseases Ethnicity (genetics) Evolution, Molecular Genetic Predisposition to Disease Glycation End Products, Advanced (adverse effects) HMGB1 Protein (physiology) Host-Parasite Interactions (genetics, immunology) Humans Immunity, Innate Life Style Major Histocompatibility Complex (genetics) Malaria (epidemiology, etiology, genetics, immunology) Nutritional Status Plasmodium (genetics, physiology) Polymorphism, Single Nucleotide Receptor for Advanced Glycation End Products (genetics, physiology) Selection, Genetic

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