PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population.

Abstract

Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. Given PSCA is reported to be overexpressed in cervical cancer and the rs2294008 can influence PSCA transcription, we aimed to determine the role of rs2294008 in susceptibility to cervical cancer. The genotyping was performed in the 1126 cases and 1237 controls. Our results showed the rs2294008 TT genotype significantly associated with a reduced risk of cervical cancer (adjusted OR = 0.55, 95% CI = 0.38-0.79; recessive model). Stratified analyses revealed that the association was restricted to the subgroups of age > 49 years, parity ≤ 1, abortion and early-stage cervical cancer. Immunohistochemistry assay showed the individuals carrying the TT genotype having lower PSCA expression than those with CC/CT genotypes. In summary, the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer.

• Authors: Shizhi Wang, Shenshen Wu, Haixia Zhu, Bo Ding, Yunlang Cai, Jing Ni, Qiang Wu, Qingtao Meng, Xin Zhang, Chengcheng Zhang, Xiaobo Li, Meilin Wang, Rui Chen, Hua Jin, Zhengdong Zhang
• Journal: Scientific reports (Sci Rep) Vol. 6 Pg. 23465 (Mar 22 2016) ISSN: 2045-2322 [Electronic] England
• PMID: 27001215 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Neoplasm
• GPI-Linked Proteins
• Neoplasm Proteins
• PSCA protein, human

Topics

• Antigens, Neoplasm (genetics)
• China
• Female
• GPI-Linked Proteins (genetics)
• Genetic Predisposition to Disease
• Humans
• Neoplasm Proteins (genetics)
• Polymorphism, Single Nucleotide
• Uterine Cervical Neoplasms (genetics)