[Elucidating hypoglycemic mechanism of Dendrobium nobile through auxiliary elucidation system for traditional Chinese medicine mechanism].

Abstract

To build the Dendrobium nobile -T2DM network, and elucidate the molecular mechanism of D. nobile to type 2 diabetes (T2DM). Collect the chemical composition of D. nobile and the targets on T2DM by retrieving database and documents, build the network of D. nobile to T2DM using the entity grammar systems inference rules. The molecular mechanism of D. nobile to T2DM includes: (1) regulating lipid metabolism by lowering triglyceride; (2) reducing insulin resistance; (3) protecting islet cells; (4) promoting the glucose-dependent insulin tropic peptide (GIP) secretion; (5) inhibiting calcium channel. Under the guidance of network pharmacology, through entity grammar systems inference rules we elucidate the molecular mechanism of D. nobile to T2DM, and provide the basis for the further development of health care products based on D. nobile.

• Authors: Man-man Li, Bai-xia Zhang, Shuai-bing He, Rao Zheng, Yan-ling Zhang, Yun Wang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 40 Issue 19 Pg. 3709-12 (Oct 2015) ISSN: 1001-5302 [Print] China
• PMID: 26975089 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channels
• Drugs, Chinese Herbal
• Hypoglycemic Agents
• Triglycerides

Topics

• Animals
• Calcium Channels (genetics, metabolism)
• Databases, Factual
• Dendrobium (chemistry)
• Diabetes Mellitus, Type 2 (drug therapy, genetics, metabolism)
• Drugs, Chinese Herbal (administration & dosage, chemistry)
• Gene Regulatory Networks (drug effects)
• Humans
• Hypoglycemic Agents (administration & dosage, chemistry)
• Insulin Resistance
• Islets of Langerhans (metabolism)
• Triglycerides (metabolism)