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Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells.

Abstract
The protective effects of kaempferol against reactive oxygen species (ROS)-induced hemolysis and its antiproliferative activity on human cancer cells were evaluated in this study. Kaempferol exhibited strong cellular antioxidant ability (CAA) with a CAA value of 59.80 ± 0.379 μM of quercetin (QE)/100 μM (EC50 = 7.74 ± 0.049 μM). Pretreatment with kaempferol significantly attenuated the ROS-induced hemolysis of human erythrocyte (87.4% hemolysis suppressed at 100 μg/mL) and reduced the accumulation of toxic lipid peroxidation product malondialdehyde (MDA). The anti-hemolytic activity of kaempferol was mainly through scavenging excessive ROS and preserving the intrinsic antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT; and glutathione peroxidase, GPx) activities in normal levels. Additionally, kaempferol showed significant antiproliferative activity on a panel of human cancer cell lines including human breast carcinoma (MCF-7) cells, human stomach carcinoma (SGC-7901) cells, human cervical carcinoma (Hela) cells and human lung carcinoma (A549) cells. Kaemperol induced apoptosis of MCF-7 cells accompanied with nuclear condensation and mitochondria dysfunction.
AuthorsWenzhen Liao, Luying Chen, Xiang Ma, Rui Jiao, Xiaofeng Li, Yong Wang
JournalEuropean journal of medicinal chemistry (Eur J Med Chem) Vol. 114 Pg. 24-32 (May 23 2016) ISSN: 1768-3254 [Electronic] France
PMID26974372 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2016 Elsevier Masson SAS. All rights reserved.
Chemical References
  • Antioxidants
  • Kaempferols
  • Protective Agents
  • Reactive Oxygen Species
  • kaempferol
Topics
  • Antioxidants (chemistry, pharmacology)
  • Cell Proliferation (drug effects)
  • Cell Survival (drug effects)
  • Dose-Response Relationship, Drug
  • Erythrocytes (drug effects, metabolism)
  • HeLa Cells
  • Hemolysis (drug effects)
  • Humans
  • Kaempferols (chemistry, pharmacology)
  • MCF-7 Cells
  • Molecular Structure
  • Neoplasms (pathology)
  • Protective Agents (chemistry, pharmacology)
  • Reactive Oxygen Species (metabolism)
  • Structure-Activity Relationship

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