Adjuvant role of radiation therapy for locally advanced laryngeal cancer without pathological lymph node metastasis.

Abstract

Conclusion The application of adjuvant RT to reduce recurrence should be tailored in cases of pathologically negative node metastasis. Objectives The treatment modality following surgical resection of advanced laryngeal cancer is determined by adverse factors. Aside from lymph node metastasis (LNM) or positive margins, definite risk factors supporting adjuvant radiation therapy (RT) have not been clearly suggested. The aim of this study was to analyze the risk factors for advanced laryngeal cancer without LNM and the role of RT. Materials and methods Pathologically T3 and T4-staged laryngeal squamous cell carcinoma without LNM were reviewed. The patients were classified into RT (+) (n = 22) and RT (-) (n = 38) groups. Results Five-year overall survival (OS) of the RT (+) and RT (-) groups was 84.4% and 83.8%, respectively. Five-year disease-specific survival of the RT (+) and RT (-) groups was 88.4% and 93.9%. Five-year local control rate of the RT (+) and RT (-) groups was 94.7% and 91.3%. The factors affecting OS were smoking history and recurrence history (p = 0.02). By multivariate analysis, smoking history and recurrence history were determining factors for 5-year OS (p = 0.024 and p = 0.047, respectively).

• Authors: Sung Hee Kim, Yoon Se Lee, Minsu Kwon, Ji Won Kim, Jong-Lyel Roh, Seung-Ho Choi, Sang Yoon Kim, Sang-Wook Lee, Soon Yuhl Nam
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 136 Issue 7 Pg. 703-10 (Jul 2016) ISSN: 1651-2251 [Electronic] England
• PMID: 26924463 (Publication Type: Comparative Study, Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (mortality, radiotherapy, surgery)
• Female
• Humans
• Laryngeal Neoplasms (mortality, radiotherapy, surgery)
• Laryngectomy
• Male
• Middle Aged
• Neck Dissection
• Radiotherapy, Adjuvant
• Republic of Korea (epidemiology)
• Retrospective Studies