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Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis.

Abstract
Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
AuthorsTiffany C Blair, Minsha Manoharan, Stephanie D Rawlings-Rhea, Ian Tagge, Steven G Kohama, Julie Hollister-Smith, Betsy Ferguson, Randall L Woltjer, Meredith C Frederick, James Pollaro, William D Rooney, Larry S Sherman, Dennis N Bourdette, Scott W Wong
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 291 Pg. 1-10 (Feb 15 2016) ISSN: 1872-8421 [Electronic] Netherlands
PMID26857488 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
CopyrightCopyright © 2015 Elsevier B.V. All rights reserved.
Chemical References
  • Antigens, CD
  • Cytokines
  • Microfilament Proteins
  • Myelin Basic Protein
  • Nerve Tissue Proteins
Topics
  • Animals
  • Antigens, CD (metabolism)
  • B-Lymphocytes (metabolism, pathology)
  • Central Nervous System (pathology)
  • Cytokines (metabolism)
  • Disease Models, Animal
  • Encephalomyelitis (embryology, pathology)
  • Lymphocytes (metabolism, pathology)
  • Macaca
  • Macrophages (metabolism, pathology)
  • Magnetic Resonance Imaging
  • Microfilament Proteins (metabolism)
  • Microglia (metabolism, pathology)
  • Multiple Sclerosis (immunology, pathology)
  • Myelin Basic Protein (metabolism)
  • Nerve Tissue Proteins (metabolism)

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