Abstract |
Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.
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Authors | Tiffany C Blair, Minsha Manoharan, Stephanie D Rawlings-Rhea, Ian Tagge, Steven G Kohama, Julie Hollister-Smith, Betsy Ferguson, Randall L Woltjer, Meredith C Frederick, James Pollaro, William D Rooney, Larry S Sherman, Dennis N Bourdette, Scott W Wong |
Journal | Journal of neuroimmunology
(J Neuroimmunol)
Vol. 291
Pg. 1-10
(Feb 15 2016)
ISSN: 1872-8421 [Electronic] Netherlands |
PMID | 26857488
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
- Antigens, CD
- Cytokines
- Microfilament Proteins
- Myelin Basic Protein
- Nerve Tissue Proteins
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Topics |
- Animals
- Antigens, CD
(metabolism)
- B-Lymphocytes
(metabolism, pathology)
- Central Nervous System
(pathology)
- Cytokines
(metabolism)
- Disease Models, Animal
- Encephalomyelitis
(embryology, pathology)
- Lymphocytes
(metabolism, pathology)
- Macaca
- Macrophages
(metabolism, pathology)
- Magnetic Resonance Imaging
- Microfilament Proteins
(metabolism)
- Microglia
(metabolism, pathology)
- Multiple Sclerosis
(immunology, pathology)
- Myelin Basic Protein
(metabolism)
- Nerve Tissue Proteins
(metabolism)
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