Abstract | OBJECTIVE: To provide a theoretical basis for the further development of new drugs, the analgesic and anti-inflammatory effects and the liver function in mice of anthocyanin from Ligustrum vicaryi were investigated. METHODS: RESULTS: The pain threshold of mice was enhanced and the times of twist body wa decreased by medium-concentration and high-concentration anthocyanin. The activity of SOD was increased and the conentrs of NO and PGE were reduced in blood serum. High-concentration anthocyanin inhibited the ear swelling , the increase of celiac capillary permeability and th granuloma hyperplasia, and increased the activities of SOD and T-AOC while decreased the content of PGE2. The activities of SOD, T-AOC. GSH-PX were increased in liver, but the morphology of liver tissues in each group had no significant changes. CONCLUSION:
Anthocyanin Ligustrum vicaryi has definite anti-inflammatory and analgesic effects, which is related to increasing the antioxidant capacity and decreasing th contents of NO and PGE2, and has not obvious damage to liver in the range of experimental concentration.
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Authors | Jing Wang, Jian-an Wang, Yu-xin Jiang, Ping-ping Zhou, Hai-hua Wang |
Journal | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
(Zhongguo Ying Yong Sheng Li Xue Za Zhi)
Vol. 31
Issue 5
Pg. 431-6
(Sep 2015)
ISSN: 1000-6834 [Print] China |
PMID | 26827536
(Publication Type: Journal Article)
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Chemical References |
- Analgesics
- Anthocyanins
- Anti-Inflammatory Agents
- Antioxidants
- Nitric Oxide
- Glutathione Peroxidase
- Superoxide Dismutase
- Dinoprostone
- Aspirin
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Topics |
- Analgesics
(chemistry)
- Animals
- Anthocyanins
(pharmacology)
- Anti-Inflammatory Agents
(chemistry)
- Antioxidants
(metabolism)
- Aspirin
(pharmacology)
- Dinoprostone
(metabolism)
- Edema
- Fruit
(chemistry)
- Glutathione Peroxidase
(metabolism)
- Ligustrum
(chemistry)
- Liver
(drug effects)
- Mice
- Nitric Oxide
- Superoxide Dismutase
(metabolism)
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