Abstract | INTRODUCTION:
Metformin is a preferred drug for starting treatment in type 2 diabetes mellitus. But, eventually most of the patients need additional drug to control blood sugar level. The choice of drug depends upon several factors including patient specific criteria, economical factors and treatment satisfaction. AIM: MATERIALS AND METHODS: It was a retrospective observational study on 50 patients each in sitagliptin and glimepiride group, who are receiving treatment for at least 12 weeks and are stable on respective treatment regimen. Glycated haemoglobin (HBA1c) was the primary measure of efficacy. Safety was assessed by checking weight gain/loss, hypoglycaemia episodes and other laboratory investigations. Patient satisfaction was assessed by Diabetes Treatment Satisfaction Questionnaire. RESULTS: The HbA1c level after 12-24 weeks of treatment was not found to be significant compared to each other or from baseline. Compared to baseline fasting plasma glucose & postprandial plasma glucose were lower in glimepiride group. Sitagliptin was associated with less episodes of hypoglycaemia. Weight gain was associated with glimepiride but it was non-significant (p=0.08). Overall treatment satisfaction score were better for sitagliptin but were not statistically significant. CONCLUSION:
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Authors | Subodh Kumar, Anuj Kumar Pathak, Dibyajyoti Saikia, Amish Kumar |
Journal | Journal of clinical and diagnostic research : JCDR
(J Clin Diagn Res)
Vol. 9
Issue 12
Pg. FC07-10
(Dec 2015)
ISSN: 2249-782X [Print] India |
PMID | 26816909
(Publication Type: Journal Article)
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