Risk Factors for Insulin Resistance, Metabolic Syndrome, and Diabetes in 248 HFE C282Y Homozygotes Identified by Population Screening in the HEIRS Study.

Abstract

BACKGROUND:

We sought to identify risk factors for insulin resistance, metabolic syndrome (MetS), and diabetes mellitus in 248 non-Hispanic white HFE C282Y homozygotes identified by population screening.

METHODS:

We analyzed observations obtained prospectively in a postscreening examination: age; sex; body mass index (BMI); systolic/diastolic blood pressure; metacarpophalangeal (MP) joint hypertrophy; hepatomegaly; complete blood counts; alanine/aspartate aminotransferase levels; elevated C-reactive protein (>0.5 mg/dL); transferrin saturation; serum ferritin; homeostasis model assessment-insulin resistance (HOMA-IR); and MetS.

RESULTS:

Twenty-six participants (10.5%) had diabetes diagnoses. A significant trend across HOMA-IR quartiles was observed only for blood neutrophils. Logistic regression on HOMA-IR fourth quartile revealed positive associations: age (P = 0.0002); male sex (P = 0.0022); and BMI (P < 0.0001). HOMA-IR fourth quartile predicted MetS (P < 0.0001). Logistic regression on diabetes revealed positive associations: age (P = 0.0012); male sex (P = 0.0068); MP joint hypertrophy (P = 0.0167); neutrophils (P = 0.0342); and MetS (P = 0.0298). Serum ferritin did not predict HOMA-IR fourth quartile, MetS, or diabetes.

CONCLUSIONS:

In screening C282Y homozygotes, age, male sex, and BMI predicted HOMA-IR fourth quartile. HOMA-IR fourth quartile alone predicted MetS. Diabetes was associated with greater age, male sex, MP joint hypertrophy, greater blood neutrophil counts, and MetS.

• Authors: James C Barton, J Clayborn Barton, Paul C Adams, Ronald T Acton
• Journal: Metabolic syndrome and related disorders (Metab Syndr Relat Disord) Vol. 14 Issue 2 Pg. 94-101 (Mar 2016) ISSN: 1557-8518 [Electronic] United States
• PMID: 26771691 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Genetic Markers
• HFE protein, human
• Hemochromatosis Protein

Topics

• Age Factors
• Aged
• Body Mass Index
• Canada (epidemiology)
• Chi-Square Distribution
• Diabetes Mellitus (diagnosis, epidemiology, genetics)
• Female
• Genetic Association Studies
• Genetic Markers
• Genetic Predisposition to Disease
• Genetic Testing
• Hemochromatosis (diagnosis, epidemiology, genetics)
• Hemochromatosis Protein (genetics)
• Homozygote
• Humans
• Insulin Resistance (genetics)
• Linear Models
• Logistic Models
• Male
• Metabolic Syndrome (diagnosis, epidemiology, genetics)
• Middle Aged
• Odds Ratio
• Phenotype
• Prevalence
• Prospective Studies
• Risk Factors
• Sex Factors
• United States (epidemiology)
• White People (genetics)