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Prenatal nicotine exposure induces poor articular cartilage quality in female adult offspring fed a high-fat diet and the intrauterine programming mechanisms.

Abstract
Prenatal nicotine exposure (PNE) induces skeletal growth retardation and dyslipidemia in offspring displaying intrauterine growth retardation (IUGR). Cholesterol accumulation resulting from cholesterol efflux dysfunction may reduce the quality of articular cartilage through fetal programming. This study evaluated the quality of articular cartilage of female adult offspring fed a high-fat diet and explored the mechanisms using a rat IUGR model established by the administration of 2.0mg/kg/d of subcutaneous nicotine from gestational days 11-20. The results demonstrated an increased OARSI (Osteoarthritis Research Society International) score and total cholesterol content, decreased serum corticosterone, and increased IGF1 and dyslipidemia with catch-up growth in PNE adult offspring. Cartilage matrix, IGF1 and cholesterol efflux pathway expression were reduced in PNE fetuses and adult offspring. Therefore, PNE induced poor articular cartilage quality in female adult offspring fed a high-fat diet via a dual programming mechanism.
AuthorsKai Tie, Yang Tan, Yu Deng, Jing Li, Qubo Ni, Jacques Magdalou, Liaobin Chen, Hui Wang
JournalReproductive toxicology (Elmsford, N.Y.) (Reprod Toxicol) Vol. 60 Pg. 11-20 (04 2016) ISSN: 1873-1708 [Electronic] United States
PMID26769161 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2016 Elsevier Inc. All rights reserved.
Chemical References
  • insulin-like growth factor-1, rat
  • Insulin-Like Growth Factor I
  • Nicotine
  • Cholesterol
  • Corticosterone
Topics
  • Animals
  • Cartilage, Articular (drug effects, metabolism)
  • Cholesterol (blood, metabolism)
  • Corticosterone (blood)
  • Diet, High-Fat
  • Female
  • Femur (metabolism)
  • Fetal Development (drug effects)
  • Fetal Growth Retardation (metabolism)
  • Fetus
  • Insulin-Like Growth Factor I (metabolism)
  • Nicotine (toxicity)
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Rats, Wistar

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