[Effects of high-flux hemodialysis on FGF-23 and micro-inflammatory state in end-stage renal diseases patients].

Abstract

OBJECTIVE:

To explore the effects of high-flux hemodialysis (HFHD) on fibroblast growth factor 23 (FGF-23) and micro-inflammatory state in end-stage renal diseases (ESRD) patients to understand the advantages of HFHD in reducing complications in ESRD patients.

METHODS:

A total of 60 subjects sheduled for hemodialysis at our hospital in 2012 were randomly divided into two groups of 3-month HFHD and 3-month low-flux hemodialysis (LFHD) (n = 30 each). The levels of serum factors, such as FGF-23, were observed before and after 3-month hemodialysis to evaluate the hemodialysis sufficiency of two groups and analyze the effects of FGF-23 related factors as well as different kinds of hemodialysis on microinflammatory state, biochemical indices and dialysis sufficiency.

RESULTS:

Before hemodialysis, no intergroup statistical difference (P > 0. 05) existed in age, gender, basic disease, nutrition and levels of hemoglobin (Hb), albumin (ALB), estimated glomerular filtration rate (eGFR), Ca2+,P3- parathyroid hormone (PTIH) and FGF-23 before treatment. After 3-month hemodialysis in two groups, there were a negative correlation between FGF-23, Ca2 + or 1, 25-(OH)2VitD3, a positive correlation between FGF-23 and ALB, P3-, PTH, C-reactive protein (CHRP) or interleukin-6 (IL-6l) and a negative correlation between FGF 23 and HFHD group (P <0. 05) and no significant correlation between FGF-23 and Hb or KT/V (P < 0. 05). Variance analyses were conducted for each factor before and after hemodialysis, indicating that Hb, ALB and Ca2+ significantly increased in both groups after 3-month hemodialysis (P <0. 05) and 1, 25-(OH)2VitD3 significantly elevated in HFHD group (P < 0. 05) but not in LFHD (> 0. 05 . Serum phosphate significantly decreased after 3-month hemodialysis in both groups (P <0. 05) and CHIP, IL-6l, PTH and FGF-23 significantly decreased in HFHD group (P <0. 05), but not in LFHD group (P >0. 05). The levels of P3-, CRP, IL-6, PTH and FGF-23 after 3-month hemodialysis were significantly lower in HFHD group than those in LFHD group (P <0. 05) while the levels of Hb and 1, 25-(OH)2VitD3 after 3-month hemodialysis were significantly elevated in HFHD group compared with those in LFHD group (P < 0. 05). And no significant inter-group difference existed in the levels of Ca2 ALB and KT/V.

CCONCLUSIONS:

Compared with LFHD, HFHD is superior in treating anemia and improving nutrition. And HFHD can better decrease FGF-23, correct calcium and phosphorous metabolic disorder and improve micro-inflammatory state.

• Authors: Zhijian Zhang, Janzhi Chen, Zhuxing Sun, Caimei Chen, Jing Xue, Xiaobin Liu, Liang Wang
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 95 Issue 26 Pg. 2074-8 (Jul 14 2015) ISSN: 0376-2491 [Print] China
• PMID: 26710869 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Albumins
• FGF23 protein, human
• Hemoglobins
• IL6 protein, human
• Interleukin-6
• Parathyroid Hormone
• Fibroblast Growth Factors
• Fibroblast Growth Factor-23
• C-Reactive Protein
• Calcium

Topics

• Albumins
• C-Reactive Protein
• Calcium
• Fibroblast Growth Factor-23
• Fibroblast Growth Factors
• Hemoglobins
• Humans
• Interleukin-6
• Kidney Failure, Chronic
• Parathyroid Hormone
• Renal Dialysis
• Renal Insufficiency, Chronic