Abstract | OBJECTIVE: To identify associations between second-trimester serum inflammatory biomarkers and preterm birth among obese women. METHODS: In this nested case-control study, we compared 65 serum inflammatory biomarkers in obese women whose pregnancies resulted in early spontaneous preterm birth (<32 weeks gestation, n = 34) to obese women whose pregnancies resulted in term birth (n = 34). These women were selected from a larger population-based California cohort. Random forest and classification and regression tree techniques were employed to identify biomarkers of importance, and adjusted odds ratios (aORs) and 95% confidence intervals (CI) were estimated using logistic regression. RESULTS: CONCLUSIONS: In this pilot study, we identified three serum biomarkers indicative of inflammation to be associated with spontaneous preterm birth among obese women: sVEGFR3, sIL-2RA and sTNFR1.
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Authors | Matthew B Wallenstein, Laura L Jelliffe-Pawlowski, Wei Yang, Suzan L Carmichael, David K Stevenson, Kelli K Ryckman, Gary M Shaw |
Journal | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
(J Matern Fetal Neonatal Med)
Vol. 29
Issue 20
Pg. 3317-22
(Oct 2016)
ISSN: 1476-4954 [Electronic] England |
PMID | 26700828
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Biomarkers
(blood)
- Case-Control Studies
- Female
- Humans
- Inflammation
(blood)
- Obesity
(blood, complications)
- Pregnancy
- Pregnancy Trimester, Second
(blood)
- Premature Birth
(blood)
- Young Adult
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