Abstract | BACKGROUND AND AIMS: METHODS: Indexed right ventricular end diastolic volume, as assessed by cardiac magnetic-resonance imaging, was classified as <100ml/m2 (Group 1, n = 5), 100-150ml/m2 (Group 2, n = 18), and >150ml/m2 (Group 3, n = 6) in 29 patients with repaired tetralogy of Fallot. Pulmonary regurgitation fraction and right ventricular ejection fraction were calculated. The serum bile acid profile, including 15 species, in these patients was determined by liquid chromatography coupled with mass spectrometry. RESULTS: Serum bile acid levels increased from Group 1 to Group 3 (2.5 ± 0.7; 4.1 ± 2.5; 6.0 ± 2.8 μmol/l, respectively) with significantly increased bile acid values in Group 3 compared to Group 1 (p≤0.05). In Group 3, but not in Group 1 and 2, a significant increase in glycine-conjugated bile acids was observed. Pulmonary regurgitation fraction increased (12 ± 1; 28 ± 16; 43 ± 3%, Groups 1-3, respectively) and right ventricular ejection fraction decreased (48.4 ± 6.4; 48.5 ± 6.5; 42.1 ± 5.3%, Groups 1-3, respectively) with rising indexed right ventricular end diastolic volume. CONCLUSIONS: These preliminary results suggest that serum bile acid levels are positively correlated with indexed right ventricular end-diastolic volume in patients with repaired tetralogy of Fallot; however, this needs to be confirmed in a larger patient cohort.
|
Authors | Gernot Grangl, Evelyn Zöhrer, Martin Köstenberger, Alexandra Jud, Günter Fauler, Hubert Scharnagl, Tatjana Stojakovic, Robert Marterer, Andreas Gamillscheg, Jörg Jahnel |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 12
Pg. e0144745
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26659834
(Publication Type: Journal Article)
|
Chemical References |
- Bile Acids and Salts
- Biomarkers
|
Topics |
- Adolescent
- Adult
- Bile Acids and Salts
(blood)
- Biomarkers
(blood)
- Child
- Chromatography, Liquid
- Female
- Humans
- Liver
(metabolism)
- Male
- Mass Spectrometry
- Myocardium
(metabolism)
- Postoperative Complications
(blood, pathology, physiopathology)
- Prospective Studies
- Pulmonary Valve Insufficiency
(blood, diagnosis, etiology, physiopathology)
- Stroke Volume
- Tetralogy of Fallot
(blood, pathology, physiopathology, surgery)
- Ventricular Function, Right
|