Vacor inhibits insulin release from islets in vitro.

Abstract

It has been reported that Vacor, a rodenticide containing N-3-pyridylmethyl-N'-p-nitrophenyl urea, causes insulin-dependent diabetes mellitus. The pathomechanism of Vacor-induced diabetes mellitus has not been clarified yet. The effect of Vacor, therefore, was studied in terms of insulin release from isolated rat pancreatic islets. Vacor suppressed glucose-stimulated insulin release, but did not affect the insulin release induced by theophylline or 12-o-tetra-decanoylphorbol 13-acetate. It is suspected that the suppression of insulin release from pancreatic islets by Vacor may contribute to the pathogenesis of Vacor-induced diabetes mellitus and that this suppression might not be related to cAMP and C-kinase.

• Authors: H Taniguchi, Y Yamashiro, M Y Chung, Y Hara, K Ishihara, K Ejiri, S Baba
• Journal: Journal of endocrinological investigation (J Endocrinol Invest) Vol. 12 Issue 4 Pg. 273-5 (Apr 1989) ISSN: 0391-4097 [Print] Italy
• PMID: 2663966 (Publication Type: Journal Article)

Chemical References

• Insulin
• Phenylurea Compounds
• Rodenticides
• Theophylline
• Glucose
• pyriminil

Topics

• Animals
• Glucose (pharmacology)
• In Vitro Techniques
• Insulin (metabolism)
• Insulin Secretion
• Islets of Langerhans (drug effects, metabolism)
• Phenylurea Compounds (pharmacology)
• Rats
• Rats, Inbred Strains
• Rodenticides (pharmacology)
• Theophylline (pharmacology)