The protective effect of tadalafil on IMA (ischemia modified albumin) levels in experimental renal ischemia-reperfusion injury.

Abstract

INTRODUCTION:

To investigate the effect of the tadalafil in experimental renal I/R injury and to evaluate these changes with IMA (nonspesific early biomarker of ischemia), NO and MDA levels.

MATERIALS AND METHODS:

Twenty four female Wistar rats were randomly divided into 3 groups (n=8): Group I, sham; Group II, 60 min I/R; Group III, 60 min I/R plus tadalafil. Tadalafil was administered via an orogastric tube (10 mg/kg) 24 h prior to the procedure. After ischemia of the left kidney and 1 h of reperfusion, blood samples were obtained, and the kidney was removed.

RESULTS:

Statistically significant histopathologic changes were exist between groups, with the most severe injury was determined in group II in comparison to the others (X(2)=21,803, P=0.000). Also mean serum IMA levels were higher in group II, but not statistically significant (19.83±7.81 U/ml, 22.26±7.14 U/ml and 19.82±7.77 U/ml, P=0.613). In addition, NO values were lower in I/R groups (P=0.049). There were no differences among the groups in terms of MDA.

CONCLUSIONS:

IMA may be used as a nonselective biomarker for IR injury before the occurrence of necrosis. Decreased IMA levels may indicate the nephroprotective effect of tadalafil in renal IR injury.

• Authors: Akin Soner Amasyali, Abdullah Akkurt, Ercan Kazan, Mustafa Yilmaz, Bulent Erol, Yuksel Yildiz, Haluk Erol
• Journal: International journal of clinical and experimental medicine (Int J Clin Exp Med) Vol. 8 Issue 9 Pg. 15766-72 ( 2015) ISSN: 1940-5901 [Print] United States
• PMID: 26629074 (Publication Type: Journal Article)