In vitro and in vivo activities of atalaphillinine and related acridone alkaloids against rodent malaria.

Abstract

Thirty acridone alkaloids obtained from Citrus, Glycosmis, or Severinia plants (members of the family Rutaceae) were tested for their antimalarial activities in vitro and in vivo. At a concentration of 10 micrograms/ml in vitro, seven of these alkaloids suppressed 90% or more of Plasmodium yoelii, which causes malaria in rodents. Atalaphillinine, when injected intraperitoneally in a daily dose of 50 mg/kg for 3 days into mice infected with 10(7) erythrocytes parasitized with Plasmodium berghei or Plasmodium vinckei, completely suppressed the development of malaria parasites, with there being no obvious acute toxic effects from the tested dose.

• Authors: H Fujioka, Y Nishiyama, H Furukawa, N Kumada
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 33 Issue 1 Pg. 6-9 (Jan 1989) ISSN: 0066-4804 [Print] United States
• PMID: 2653215 (Publication Type: Journal Article)

Chemical References

• Acridines
• Alkaloids
• Antimalarials
• atalaphillinine

Topics

• Acridines
• Alkaloids (pharmacology, therapeutic use)
• Animals
• Antimalarials (pharmacology, therapeutic use)
• Drug Evaluation, Preclinical
• Malaria (drug therapy)
• Male
• Mice
• Mice, Inbred ICR
• Plasmodium (drug effects)
• Plasmodium berghei (drug effects)
• Plasmodium yoelii (drug effects)