[Bone quality].

Abstract

Bone quality is thought to encompass the structural and material properties of bone. Bone collagen crosslinking plays important roles in bone strength. The quantitative and qualitative deterioration of lysyl oxidase control and non enzymatic cross-links (advanced glycation end products, AGEs, pentosidine) of collagen in patients with osteoporotic femoral neck fracture and diabetes, and chronic kidney disease might be affected by increased oxidative stress and glycation. A higher urinary or plasma pentosidine and homocysteine levels were an independent risk factor for osteoporotic fracture. If confirmed in large, prospective trials, measurements of serum homocysteine and serum or urine levels of pentosidine might be characterized as markers reflecting bone collagen deterioration.

• Authors: Mitsuru Saito, Keishi Marumo
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 73 Issue 10 Pg. 1665-72 (Oct 2015) ISSN: 0047-1852 [Print] Japan
• PMID: 26529928 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Glycation End Products, Advanced
• Collagen

Topics

• Animals
• Biomarkers (analysis)
• Bone Density
• Bone and Bones (metabolism)
• Collagen (metabolism)
• Glycation End Products, Advanced (metabolism)
• Humans
• Osteoporosis (metabolism)