Osteoporotic Fractures

01/01/2008 - "Oral bisphosphonates are effective for reducing the risk of osteoporotic fractures and are an important treatment option for patients at risk for this condition. "
04/01/2016 - "In patients 75 years and older, nonadherence with oral bisphosphonates can be associated with significantly greater short-term risk of osteoporotic fractures and higher utilization of health care services."
01/01/2020 - "Bisphosphonates are effective in reducing hip and osteoporotic fractures. "
12/01/2017 - "Bisphosphonates are effective in preventing osteoporotic fractures. "
02/01/2017 - "The efficacy of bisphosphonates for osteoporotic fracture has been consistently reported in recent randomized controlled trials (RCTs) enrolling hundreds of patients. "

03/01/1990 - "Although the efficacy of exercise and calcium supplementation to prevent osteoporotic fractures has not been well established, these measures are commonly advocated by both generalists and subspecialists. "
06/01/2019 - "However, data regarding the efficacy of calcium obtained either through the diet or in the form of medicinal supplementation, for prevention of bone loss and osteoporotic fractures in the elderly is conflicting. "
01/01/2019 - "To determine if genetically increased serum calcium levels are associated with improved bone mineral density and a reduction in osteoporotic fractures. "
05/01/2002 - "Furthermore, our results suggest that adequate calcium intake may help to enhance bone mass, thus decreasing the risk of osteoporotic fracture later in life."
02/15/2011 - "In three of the five trials, subgroup analysis of the most treatment-adherent participants indicated significant reductions in osteoporotic fracture risk with calcium supplement use. "

01/01/2016 - "Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteoporotic fractures and hip above 8.8 and 2.5 %, respectively. "
01/01/2020 - "Conclusion: The findings support the view that oral alendronate is cost-effective for the treatment of osteoporotic fractures in Chinese postmenopausal women. "
06/01/2005 - "These data show that alendronate is effective in reducing the risk of symptomatic osteoporotic fractures across a spectrum of ages. "
01/01/2013 - "Characteristics of patients who suffer major osteoporotic fractures despite adhering to alendronate treatment: a National Prescription registry study."
01/01/2011 - "Two thousand seven hundred seventy-seven women aged 55 to 80 randomized to the placebo arms of the Fracture Intervention Trial, a randomized controlled trial of the effect of alendronate on risk for osteoporotic fractures. "

03/01/2012 - "Adequate levels of vitamin D correlate with greater bone mineral density, lower rates of osteoporotic fractures, and improved neuromuscular function. "
12/01/2010 - "The efficacy of vitamin D on osteoporotic fractures is thought to be through direct effects on bone and indirect effects on muscles that help to prevent falls. "
04/15/2009 - "Epidemiological studies revealed a dose-dependent association between serum 25-OHD levels and pulmonary function so that adequate vitamin D supplementation may extend beyond its protection against osteoporotic fractures. "
12/01/2022 - "The aim of the present study was to compare the serum sclerostin levels in osteoporotic and non-osteoporotic fracture patients and to assess the correlation of the sclerostin levels with bone mineral density and vitamin D status. "
01/01/2022 - "Vitamin D supplementation with daily dose of 800 to 1,000 mg was associated with lower risks of osteoporotic fracture and fall (pooled relative risk [RR], 0.87; 95% confidence interval [CI], 0.78 to 0.97 and RR, 0.91; 95% CI, 0.85 to 0.98), while studies with <800 or >1,000 mg/day did not. "

03/01/2013 - "Twice-yearly denosumab treatment is associated with markedly improved bone mineral density (BMD) and cortical and trabecular bone strength, and significantly reduced osteoporotic fracture. "
10/01/2013 - "So, promising results in terms of therapeutic efficacy and reliability make desirable the wide clinical use of denosumab for the treatment of osteoporotic fractures in the near future."
01/01/2019 - "Only one study demonstrated greater osteoporotic fracture reduction with denosumab treatment. "
01/01/2019 - "Adjusting for prior fracture, the risk of having a subsequent on-study osteoporotic fracture was lower in the combined denosumab group vs placebo (hazard ratio [95% CI]: 0.59 [0.43-0.81]; P = 0.0012). "
01/01/2019 - "The risk of subsequent osteoporotic fractures is decreased in subjects experiencing fracture while on denosumab: results from the FREEDOM and FREEDOM Extension studies."

01/01/2016 - "Given the willingness-to-pay threshold, raloxifene treatment was not cost-effective for treatment of osteoporotic fractures in postmenopausal Chinese women. "
01/01/2016 - "Raloxifene treatment of osteoporotic fractures is clinically effective, but economic evidence in support of raloxifene reimbursement is lacking in the People's Republic of China. "
05/01/2004 - "These data suggest that the efficacy of raloxifene in reducing vertebral fractures is largely independent of the presence of clinical risk factors for osteoporotic fractures."
05/01/2004 - "The efficacy of raloxifene in reducing vertebral fractures is largely independent of the presence of clinical risk factors for osteoporotic fractures. "
06/01/2008 - "In this review, we provide an overview of the evidence accumulated to data on the effect of raloxifene in the prophylaxis of osteoporotic fractures. "

06/01/2013 - "Recently, open-label extensions of the SOTI and TROPOS trials up to 8 and, recently, 10 years have confirmed the sustained efficacy of strontium ranelate in increasing BMD, the long-term safety profile and the high compliance to treatment, independently from baseline BMD or other risk factors for osteoporotic fractures. "
02/01/2007 - "Strontium ranelate was shown to be clinically effective in the prevention of osteoporotic fractures. "
10/01/2009 - "Continuous broad protection against osteoporotic fractures with strontium ranelate."
02/01/2003 - "In a phase II study, the effect of strontium ranelate in postmenopausal women with vertebral osteoporotic fractures was assessed during a double-blind, placebo-controlled trial. "
01/01/2020 - "The treatment with strontium ranelate can effectively improve the BMP-2 and bone mechanical properties of the rats with osteoporotic hindlimb fracture in the healing stage and accelerate the healing progress, which could be proved to be an efficacious means in treating osteoporotic fracture."

09/01/2021 - "The efficacy of romosozumab to prevent osteoporotic fractures is remarkable. "
08/01/2021 - "Efficacy of romosozumab on clinical fracture, osteoporotic fracture, and MOF is significantly greater in patients at high baseline fracture risk compared with placebo."
05/01/2021 - "This review focuses on the mechanism of action of sclerostin and summarizes clinical studies that demonstrated the efficacy of romosozumab to increase bone mineral density and reduce osteoporotic fractures, as well as its cardiovascular safety."
01/01/2019 - "In clinical trials, a sclerostin antibody (romosozumab, Amgen Inc., UCB Brussels) increases bone formation and lowers the risk of osteoporotic fractures. "
01/01/2021 - "Romosozumab offers an alternative for patients with a high risk of osteoporotic fractures. "

01/01/2021 - "Teriparatide has proven efficacy in reducing osteoporotic fractures, but with substantial cost. "
08/01/2019 - "Clinical studies showed that Teriparatide accelerated fracture healing in patients with osteoporotic fracture of the pelvis, hip, wrist and shoulder. "
02/01/2017 - "A better understanding of the role of teriparatide on osteoporotic fractures requires greater evidences from large volume prospective trials."
01/01/2016 - "However, more clinical studies are warranted in order to determine whether the results are applicable to males and the clinical indications for teriparatide after osteoporotic fractures. "
01/01/2016 - "Recent clinical studies have suggested a role for teriparatide in accelerating healing for osteoporotic fractures. "

05/01/2002 - "The efficacy of nasal calcitonin treatment to reduce vertebral fracture rate has been best examined in the PROOF (Prevent Recurrence of Osteoporotic Fractures) study. "
09/01/2003 - "The Prevent Recurrence Of Osteoporotic Fractures (PROOF) study has shown a significant decrease in the risk of vertebral fracture in patients treated with calcitonin 200 IU. "
05/01/2002 - "Currently, there is still no prospective, placebo-controlled study with a sufficient number of patients that demonstrates that long-term parenteral calcitonin administration reduces the risk of osteoporotic fractures. "
09/01/1993 - "Calcitonin has a specific role in prevention and treatment of osteoporotic fractures. "
06/04/1991 - "In case of osteoporotic fractures prescription of calcitonin may be considered."

10/01/1996 - "NaF therapy stimulates bone formation and may be effective in preventing osteoporotic fractures. "
06/01/2006 - "Bone markers can provide a prognostic information about the risk of osteoporotic fracture and are useful tools for monitoring the efficacy of antiresorptive therapy. "
01/01/2022 - "New therapies may help to prevent osteoporotic fractures other than through increasing bone mineral density (BMD). "
04/01/2023 - "Clinical Evaluation of the Osteoporotic Fracture Treatment Score (OF-Score): Results of the Evaluation of the Osteoporotic Fracture Classification, Treatment Score and Therapy Recommendations (EOFTT) Study."
01/01/2020 - "However, observational studies have reported an association between PPI therapy and osteoporotic fractures. "

07/10/2015 - "Percutaneous vertebroplasty (PVP) has been demonstrated to be effective in the treatment of osteoporotic fracture. "
01/01/2020 - "To assess the safety and efficacy of early vertebroplasty for acute painful vertebral osteoporotic fractures within 3 weeks of fracture onset in the VAPOUR study. "
10/01/2016 - "Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial."
12/01/2010 - "The aim of this study was to evaluate feasibility and efficacy of navigated percutaneous screw fixation combined with multisegmental vertebroplasty for the treatment of osteoporotic fractures not suitable for monosegmental cement augmentation in patients with severe osteoporotic changes of the vertebral column and/or progressive kyphotic deformation. "
05/01/2021 - "Osteoporotic fractures can be cured by vertebroplasty. "

10/01/2014 - "Secondary prevention of osteoporotic fractures in Amiens University Hospital has improved since the creation of the FLS, with encouragingly high treatment initiation and persistence rates."
09/01/2019 - "Secondary prevention of osteoporotic fractures has improved since the implementation of the FLS. "
10/01/2014 - "Secondary prevention of osteoporotic fractures has improved since the creation of the FLS. "
01/23/2008 - "To assess the efficacy of residronate in the primary and secondary prevention of osteoporotic fractures in postmenopausal women. "
01/01/2022 - "This study aimed to quantify the relative importance of barriers to better secondary prevention of osteoporotic fractures and of care expectations expressed by patients with osteoporotic fractures in France. "

06/15/2010 - "Among the several therapeutical interventions, hormone replacement therapy (HRT) was traditionally seen as the gold standard for preventing osteoporotic fractures in postmenopausal women, as well as for the management of menopausal symptoms. "
03/01/2004 - "The Women's Health Initiative Study (WHI) reported that hormone replacement therapy (HRT) prevented osteoporotic fractures. "
04/01/2001 - "The aim of this study was to model the effect of short (3-year) treatments with hormone replacement therapy (HRT) at the time of menopause on the risk of osteoporotic fracture, and to assess the impact of strategies to target high-risk individuals. "
06/01/2011 - "A review of the role of hormone replacement therapy in younger women with significant risk of osteoporotic fractures may be timely in these circumstances."
08/31/2006 - "Hormone Replacement Therapy is not applied in prevention of osteoporotic fracture, however, it is still in use in treatment of disorders of menopause. "

03/01/2020 - "The authors present the first report of a fracture of the tip of a kyphoplasty curette inside the vertebral body, which occurred during a procedure in a patient with non-osteoporotic fracture. This highlights the need of further biomechanical research focused on the shear load failure properties of such type of pre-bent curettes."
11/01/2019 - "From April 2014 to December 2016, 50 cases (55 vertebrae) of thoracic osteoporotic fractures were treated with balloon kyphoplasty using the extrapedicular approach. "
08/09/2017 - "Kyphoplasty is a proven minimally invasive procedure for the treatment of patients with osteoporotic fractures. "
01/01/2017 - "Kyphoplasty is frequently used for the treatment of painful osteoporotic fractures. "
12/01/2015 - "Balloon kyphoplasty of T8 in an osteoporotic fracture."