Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest.

Abstract

Cytokines are well known mediators of numerous physiological and pathological processes. They contribute to the regulation of normal hematopoiesis but increasing data suggest that they also have a clinical impact in some hematopoietic malignancies. In particular, there is evidence that cytokines are implicated in the functional symptoms of Philadelphia negative myeloproliferative neoplasms (Ph- MPNs), suggesting that evaluation of circulating levels of cytokines could be of clinical interest for the characterization of patients at the time of diagnosis and for disease prognosis. In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. Phenotypic correlation, prognostic value of cytokines, and impact of JAK inhibitors are also discussed.

• Authors: Julie Mondet, Kais Hussein, Pascal Mossuz
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2015 Pg. 670580 ( 2015) ISSN: 1466-1861 [Electronic] United States
• PMID: 26525644 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers
• Cytokines
• Janus Kinases

Topics

• Animals
• Biomarkers (metabolism)
• Cytokines (blood, metabolism)
• Disease Progression
• Gene Expression Regulation
• Granulocytes (metabolism)
• Humans
• Inflammation (blood)
• Janus Kinases (antagonists & inhibitors)
• Myeloproliferative Disorders (blood, diagnosis)
• Phenotype
• Philadelphia Chromosome
• Primary Myelofibrosis (blood, diagnosis)
• Prognosis