Expression of Toll-Like Receptors in Chronic Histiocytic Intervillositis of the Placenta.

Abstract

Chronic histiocytic intervillositis of the placenta (CHI) shows monocytic/histiocytic infiltration of the intervillous space. Placental malaria has a CHI-like histopathology and induces an aberrant expression of Toll-like receptors (TLR) 3, 7-9. We hypothesized that, similar to placental malaria, CHI could be associated with increased TLR expression. TLR1-10 and other inflammation-associated factors were analyzed by real-time PCR and immunohistochemistry. A total of 31 formalin-fixed and paraffin-embedded placenta samples were evaluated: CHI (n = 9), and for control purposes, villitis of unknown etiology (VUE, n = 8) and placentas without inflammation (n = 14). CHI shows increased expression of monocytic TLR1, a receptor which is involved in bacterial lipopolysaccharide (LPS)-induced inflammation. This could indicate a TLR1-mediated immune mechanism in the placenta (e.g. triggered by transient, clinically inapparent maternal bacteraemia) which leads to massive monocytic/histiocytic accumulation in the intervillous space. The increased expression of TLR1 with no increased expression of TLR3 and TLR7-9 is different from that in malaria.

• Authors: Kais Hussein, Angelika Stucki-Koch, Hans Kreipe, Henning Feist
• Journal: Fetal and pediatric pathology (Fetal Pediatr Pathol) Vol. 34 Issue 6 Pg. 407-12 ( 2015) ISSN: 1551-3823 [Electronic] England
• PMID: 26503894 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Toll-Like Receptors

Topics

• Adolescent
• Adult
• Chorionic Villi (immunology, metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Inflammation (immunology, metabolism, pathology)
• Placenta Diseases (immunology, metabolism, pathology)
• Pregnancy
• Real-Time Polymerase Chain Reaction
• Toll-Like Receptors (analysis, biosynthesis)
• Young Adult