Profiles of responses of immunological factors to different subtypes of Kawasaki disease.
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| Abstract | BACKGROUND: The responses of immunological factors to different subtypes of Kawasaki disease (KD) remain poorly understood. METHODS: We recruited 388 patients with KD, 160 patients with infectious febrile disease and 85 normal children who served as control subjects. Both the levels and percentages of T lymphocyte subsets, natural killer cells (NK cells) and B cells were analyzed via flow cytometry. The levels of serum IgG, IgM, IgA and C3, C4 were assessed via velocity scatter turbidimetry. RESULTS: The most significant differences noted between the patients with infectious febrile disease and the normal children were the elevated levels of B cells, C3 and the ratio of CD4/CD8, and the decreased levels of CD8+ T cells and NK cells, as well as the moderate increase in the absolute value of the CD3+ cells. The decreased T cell levels and the elevated B cell levels were helpful in distinguishing typical KD from atypical KD; the elevated T cell levels, the elevated NK cell and B cell levels and the decreased B cell levels were helpful in predicting the effectiveness of IVIG; low C3 and C4 levels were linked with prodromal infections. CONCLUSIONS: Lymphocytes subsets and complement markers may be useful in differentiating among the different subtypes of KD and in helping clinicians understand the pathophysiology of KD.
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| Authors | Yan Ding, Gang Li, Li-Juan Xiong, Wei Yin, Jie Liu, Fan Liu, Rui-Geng Wang, Kun Xia, Shu-Ling Zhang, Lei Zhao |
| Journal | BMC musculoskeletal disorders (BMC Musculoskelet Disord) Vol. 16 Pg. 315 (Oct 23 2015) ISSN: 1471-2474 [Electronic] England |
| PMID | 26497060 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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