Resveratrol, sirtuins, and viruses.

Abstract

Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. Over the past several decades, a great deal of research has identified diverse biological roles associated with resveratrol, including anti-oxidant, anti-proliferation, anti-inflammation, anti-cancer, anti-fungal, and antiviral activities. Such biological activities of resveratrol are likely mediated through multiple cellular targets or pathways, such as sirtuins, a family of NAD(+)-dependent deacetylases. In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. A working model about the effects of resveratrol on virus infection is proposed to stimulate further researches on this exciting topic.

• Authors: Tao Yang, Shugang Li, Xuming Zhang, Xiaowu Pang, Qinlu Lin, Jianzhong Cao
• Journal: Reviews in medical virology (Rev Med Virol) Vol. 25 Issue 6 Pg. 431-45 (Nov 2015) ISSN: 1099-1654 [Electronic] England
• PMID: 26479742 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 John Wiley & Sons, Ltd.

Chemical References

• Antiviral Agents
• Biological Products
• Stilbenes
• Sirtuins
• Resveratrol

Topics

• Animals
• Antiviral Agents (metabolism)
• Biological Products (metabolism)
• Humans
• Resveratrol
• Sirtuins (metabolism)
• Stilbenes (metabolism)
• Viruses (drug effects)