Objectively Measured Sedentary Time and Cardiometabolic Biomarkers in US Hispanic/Latino Adults: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Abstract

BACKGROUND:

Sedentary behavior is recognized as a distinct construct from lack of moderate-vigorous physical activity and is associated with deleterious health outcomes. Previous studies have primarily relied on self-reported data, whereas data on the relationship between objectively measured sedentary time and cardiometabolic biomarkers are sparse, especially among US Hispanics/Latinos.

METHODS AND RESULTS:

We examined associations of objectively measured sedentary time (via Actical accelerometers for 7 days) and multiple cardiometabolic biomarkers among 12 083 participants, aged 18 to 74 years, from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos of diverse backgrounds (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) were recruited from 4 US cities between 2008 and 2011. Sedentary time (<100 counts/min) was standardized to 16 hours/d of wear time. The mean sedentary time was 11.9 hours/d (74% of accelerometer wear time). After adjustment for moderate-vigorous physical activity and confounding variables, prolonged sedentary time was associated with decreased high-density lipoprotein cholesterol (P=0.04), and increased triglycerides, 2-hour glucose, fasting insulin, and homeostatic model assessment of insulin resistance (all P<0.0001). These associations were generally consistent across age, sex, Hispanic/Latino backgrounds, and physical activity levels. Even among individuals meeting physical activity guidelines, sedentary time was detrimentally associated with several cardiometabolic biomarkers (diastolic blood pressure, high-density lipoprotein cholesterol, fasting and 2-hour glucose, fasting insulin and homeostatic model assessment of insulin resistance; all P<0.05).

CONCLUSIONS:

Our large population-based, objectively derived data showed deleterious associations between sedentary time and cardiometabolic biomarkers, independent of physical activity, in US Hispanics/Latinos. Our findings emphasize the importance of reducing sedentary behavior for the prevention of cardiometabolic diseases, even in those who meet physical activity recommendations.

• Authors: Qibin Qi, Garrett Strizich, Gina Merchant, Daniela Sotres-Alvarez, Christina Buelna, Sheila F Castañeda, Linda C Gallo, Jianwen Cai, Marc D Gellman, Carmen R Isasi, Ashley E Moncrieft, Lisa Sanchez-Johnsen, Neil Schneiderman, Robert C Kaplan
• Journal: Circulation (Circulation) Vol. 132 Issue 16 Pg. 1560-9 (Oct 20 2015) ISSN: 1524-4539 [Electronic] United States
• PMID: 26416808 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 American Heart Association, Inc.

Chemical References

• Biomarkers
• Cholesterol, HDL
• Insulin

Topics

• Adolescent
• Adult
• Aged
• Biomarkers
• Cholesterol, HDL (blood)
• Hispanic or Latino
• Humans
• Insulin (blood)
• Insulin Resistance
• Middle Aged
• Sedentary Behavior
• Time Factors