The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk.

Abstract

BACKGROUND:

A large proportion of colorectal cancers are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia, and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs), which may promote colorectal cancer through their proinflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of colorectal cancer.

METHODS:

A total of 1,055 colorectal cancer cases (colon n = 659; rectal n = 396) were matchced (1:1) to control subjects. Circulating glycer-AGEs were measured by a competitive ELISA. Multivariable conditional logistic regression models were used to calculate ORs and 95% confidence intervals (95% CI), adjusting for potential confounding factors, including smoking, alcohol, physical activity, body mass index, and diabetes status.

RESULTS:

Elevated glycer-AGEs levels were not associated with colorectal cancer risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82-1.49). Subgroup analyses showed possible divergence by anatomical subsites (OR for colon cancer, 0.83; 95% CI, 0.57-1.22; OR for rectal cancer, 1.90; 95% CI, 1.14-3.19; Pheterogeneity = 0.14).

CONCLUSIONS:

In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer.

IMPACT:

Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in colorectal cancer development.

• Authors: So Yeon Kong, Masayoshi Takeuchi, Hideyuki Hyogo, Gail McKeown-Eyssen, Sho-Ichi Yamagishi, Kazuaki Chayama, Peter J O'Brien, Pietro Ferrari, Kim Overvad, Anja Olsen, Anne Tjønneland, Marie-Christine Boutron-Ruault, Nadia Bastide, Franck Carbonnel, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona Lagiou, Effie Vasilopoulou, Giovanna Masala, Valeria Pala, Maria Santucci De Magistris, Rosario Tumino, Alessio Naccarati, H B Bueno-de-Mesquita, Petra H Peeters, Elisabete Weiderpass, J Ramón Quirós, Paula Jakszyn, María-José Sánchez, Miren Dorronsoro, Diana Gavrila, Eva Ardanaz, Martin Rutegård, Hanna Nyström, Nicholas J Wareham, Kay-Tee Khaw, Kathryn E Bradbury, Isabelle Romieu, Heinz Freisling, Faidra Stavropoulou, Marc J Gunter, Amanda J Cross, Elio Riboli, Mazda Jenab, W Robert Bruce
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 24 Issue 12 Pg. 1855-63 (Dec 2015) ISSN: 1538-7755 [Electronic] United States
• PMID: 26404963 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: ©2015 American Association for Cancer Research.

Chemical References

• Glycation End Products, Advanced
• Glyceraldehyde

Topics

• Case-Control Studies
• Cohort Studies
• Colorectal Neoplasms (blood, epidemiology)
• Europe (epidemiology)
• Female
• Glycation End Products, Advanced (blood)
• Glyceraldehyde (blood)
• Humans
• Logistic Models
• Male
• Middle Aged
• Prospective Studies
• Risk Factors