Abstract | AIMS/HYPOTHESIS: Studies on weight cycling and the risk of type 2 diabetes have revealed inconsistent results, possibly due to differences in the definition of weight fluctuations. Here, we investigated whether weight cycling during adulthood is related to diabetes risk in a large cohort study, using a complementary approach to define patterns of weight development. METHODS: RESULTS: A priori defined weight cycling was associated with increased diabetes risk, compared with stable weight (HR 1.36 [95% CI 1.09, 1.68]). No significant association between FPCA-derived weight cycling and risk of diabetes was observed after adjustment for concurrent weight patterns (HR 1.19 [95% CI 0.89, 1.60]). Subgroup analyses showed that FPCA-derived weight cycling during net weight gain was associated with a higher risk of diabetes (HR 1.68 [95% CI 1.14, 2.48]). A priori defined weight gain (HR 2.08 [95% CI 1.60, 2.70]) was more clearly related to the risk of diabetes than FPCA-derived weight gain (HR 1.20 [95% CI 0.95, 1.51]), while no significant associations were observed for weight loss. CONCLUSIONS/INTERPRETATION:
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Authors | Jasmine Neamat-Allah, Myrto Barrdahl, Anika Hüsing, Verena A Katzke, Ursula Bachlechner, Annika Steffen, Rudolf Kaaks, Matthias B Schulze, Heiner Boeing, Tilman Kühn |
Journal | Diabetologia
(Diabetologia)
Vol. 58
Issue 12
Pg. 2718-25
(Dec 2015)
ISSN: 1432-0428 [Electronic] Germany |
PMID | 26376796
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Body Mass Index
- Body Weight
- Cohort Studies
- Diabetes Mellitus, Type 2
(epidemiology)
- Educational Status
- Female
- Germany
(epidemiology)
- Humans
- Incidence
- Male
- Middle Aged
- Principal Component Analysis
- Prospective Studies
- Risk Assessment
- Smoking
(epidemiology)
- Weight Gain
- Weight Loss
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