Abstract | BACKGROUND: METHODS AND MATERIALS: In this double blind, randomized trial, 100 RRMS patients with Extended disability status score (EDSS)<6 were allocated into 3 groups: "Group A" who received co-supplemented hemp seed and evening primrose oils along with advised Hot nature diet; "Group B", who received olive oil; "Group C", who received the co-supplemented oils. Clinically EDSS and functional score as well as biochemical parameters [blood cells polyunsaturated fatty acid (PUFA), FADS2, sPLA2] were assessed at baseline and after 6 months. RESULTS: Mean follow-up was 180±2.9SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration 6.80±4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in EDSS and functional score were found in the groups A and C while EDSS and pyramidal score showed significant increase in group B. Alteration of biochemical parameters showed improvement in groups A and C whereas there was worsening condition for group B after the intervention. CONCLUSION: The co-supplemented hemp seed and evening primrose oils with Hot nature diet can have beneficial effects in improving clinical symptoms and signs in RRMS patients which were confirmed by regulation of surface-membrane enzymes.
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Authors | Soheila Rezapour-Firouzi, Seyed Rafie Arefhosseini, Mehrangiz Ebrahimi-Mamaghani, Behzad Baradaran, Elyar Sadeghihokmabad, Somaiyeh Mostafaei, Mohammadali Torbati, Mahtaj Chehreh |
Journal | Complementary therapies in medicine
(Complement Ther Med)
Vol. 23
Issue 5
Pg. 652-7
(Oct 2015)
ISSN: 1873-6963 [Electronic] Scotland |
PMID | 26365444
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Linoleic Acids
- Plant Oils
- evening primrose oil
- gamma-Linolenic Acid
- Fatty Acid Desaturases
- FADS2 protein, human
- Phospholipases A2, Secretory
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Topics |
- Adult
- Cannabis
- Double-Blind Method
- Fatty Acid Desaturases
(blood)
- Female
- Humans
- Linoleic Acids
(administration & dosage, therapeutic use)
- Male
- Multiple Sclerosis
(diet therapy)
- Oenothera biennis
- Phospholipases A2, Secretory
(blood)
- Plant Oils
(administration & dosage, therapeutic use)
- Seeds
- gamma-Linolenic Acid
(administration & dosage, therapeutic use)
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