Targeted nanomedicine for prostate cancer therapy: docetaxel and curcumin co-encapsulated lipid-polymer hybrid nanoparticles for the enhanced anti-tumor activity in vitro and in vivo.

Abstract

OBJECTIVE:

Docetaxel (DTX) remains the only effective drug for prolonging survival and improving quality of life of metastatic castration-resistant prostate cancer (mCRPC) patients. Combination anticancer therapy encapsulating DTX and another extract of traditional Chinese medicine is one nano-sized drug delivery system promising to generate synergistic anticancer effects, to maximize the treatment effect, and to overcome multi-drug resistance. The purpose of this study is to construct lipid-polymer hybrid nanoparticles (LPNs) as nanomedicine for co-encapsulation of DTX and curcumin (CUR).

METHODS:

DTX and CUR co-encapsulated LPNs (DTX-CUR-LPNs) were constructed. DTX-CUR-LPNs were evaluated in terms of particles size, zeta potential, drug encapsulation, and drug delivery. The cytotoxicity of the LPNs was evaluated on PC-3 human prostate carcinoma cells (PC3 cells) by MTT assays. In vivo anti-tumor effects were observed on the PC3 tumor xenografts in mice.

RESULTS:

The particle size of DTX-CUR-LPNs was 169.6 nm with a positive zeta potential of 35.7 mV. DTX-CUR-LPNs showed highest cytotoxicity and synergistic effect of two drugs in tumor cells in vitro. In mice-bearing PC-3 tumor xenografts, the DTX-CUR-LPNs inhibited tumor growth to a greater extent than other contrast groups, without inducing any obvious side effects.

CONCLUSION:

According to these results, the novel nanomedicine offers great promise for the dual drugs delivery to the prostate cancer cells, showing the potential of synergistic combination therapy for prostate cancer.

• Authors: Jieke Yan, Yuzhen Wang, Xufeng Zhang, Shuangde Liu, Chuan Tian, Hongwei Wang
• Journal: Drug delivery (Drug Deliv) Vol. 23 Issue 5 Pg. 1757-62 (Jun 2016) ISSN: 1521-0464 [Electronic] England
• PMID: 26203689 (Publication Type: Journal Article)

Chemical References

• Drug Carriers
• Lipids
• Polymers
• Taxoids
• Docetaxel
• Curcumin

Topics

• Animals
• Cell Line, Tumor
• Curcumin (administration & dosage, pharmacology)
• Docetaxel
• Drug Carriers
• Drug Delivery Systems
• Heterografts (chemistry, drug effects)
• Humans
• Lipids (chemistry)
• Male
• Mice
• Nanomedicine (methods)
• Particle Size
• Polymers (chemistry)
• Prostatic Neoplasms (chemistry, drug therapy)
• Taxoids (administration & dosage, pharmacology)