Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins.

Abstract

Recent functional studies on chondroitin sulfate-dermatan sulfate (CS-DS) demonstrated its indispensable roles in various biological events including brain development and cancer. CS-DS proteoglycans exert their physiological activity through interactions with specific proteins including growth factors, cell surface receptors, and matrix proteins. The characterization of these interactions is essential for regulating the biological functions of CS-DS proteoglycans. Although amino acid sequences on the bioactive proteins required for these interactions have already been elucidated, the specific saccharide sequences involved in the binding of CS-DS to target proteins have not yet been sufficiently identified. In this review, recent findings are described on the interaction between CS-DS and some proteins which are especially involved in the central nervous system and cancer development/metastasis.

• Authors: Shuji Mizumoto, Shuhei Yamada, Kazuyuki Sugahara
• Journal: Current opinion in structural biology (Curr Opin Struct Biol) Vol. 34 Pg. 35-42 (Oct 2015) ISSN: 1879-033X [Electronic] England
• PMID: 26164146 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015. Published by Elsevier Ltd.

Chemical References

• Extracellular Matrix Proteins
• Intercellular Signaling Peptides and Proteins
• Receptor for Advanced Glycation End Products
• Receptors, Cell Surface
• dermatan sulfate chondroitin sulfate
• Dermatan Sulfate
• Chondroitin Sulfates

Topics

• Animals
• Chondroitin Sulfates (chemistry, metabolism)
• Dermatan Sulfate (analogs & derivatives, chemistry, metabolism)
• Extracellular Matrix Proteins (chemistry, metabolism)
• Humans
• Intercellular Signaling Peptides and Proteins (chemistry, metabolism)
• Neoplasm Metastasis
• Neoplasms (metabolism, pathology)
• Neuronal Plasticity
• Neurons (metabolism)
• Protein Binding
• Receptor for Advanced Glycation End Products (metabolism)
• Receptors, Cell Surface (chemistry, metabolism)
• Wnt Signaling Pathway