Treatment of secondary hyperparathyroidism in patients on maintenance hemodialysis.

Abstract

The effects of CaCO3 were investigated in 7 patients undergoing maintenance hemodialysis who had been treated with 1 microgram/day 1 alpha (OH)D3 and 2 g/day Al(OH)3. CaCO3 (3 g/day) was administered instead of Al(OH)3. The levels of serum total calcium and ionized calcium were significantly increased, the level of C-terminal parathyroid hormone was appreciably decreased and the levels of serum aluminum in all patients were reduced. There were no significant changes in the levels of serum phosphate, calcium x phosphate product, alkaline phosphatase, calcitonin, magnesium and bicarbonate. It is concluded that 3 g/day CaCO3 is equivalent to 2 g/day Al(OH)3 in terms of its phosphate-binding effect, and the prescription of CaCO3 together with 1 alpha (OH)D3 ameliorates secondary hyperparathyroidism.

• Authors: K Okada, S Takahashi, Y Nagura, M Hatano
• Journal: Nihon Jinzo Gakkai shi (Nihon Jinzo Gakkai Shi) Vol. 31 Issue 10 Pg. 1085-9 (Oct 1989) ISSN: 0385-2385 [Print] Japan
• PMID: 2615019 (Publication Type: Journal Article)

Chemical References

• Aluminum Hydroxide
• Calcium Carbonate

Topics

• Adult
• Aged
• Aluminum Hydroxide (therapeutic use)
• Calcium Carbonate (therapeutic use)
• Female
• Humans
• Hyperparathyroidism, Secondary (drug therapy, etiology)
• Male
• Middle Aged
• Renal Dialysis (adverse effects)