Treatment of secondary hyperparathyroidism in patients on maintenance hemodialysis.

The effects of CaCO3 were investigated in 7 patients undergoing maintenance hemodialysis who had been treated with 1 microgram/day 1 alpha (OH)D3 and 2 g/day Al(OH)3. CaCO3 (3 g/day) was administered instead of Al(OH)3. The levels of serum total calcium and ionized calcium were significantly increased, the level of C-terminal parathyroid hormone was appreciably decreased and the levels of serum aluminum in all patients were reduced. There were no significant changes in the levels of serum phosphate, calcium x phosphate product, alkaline phosphatase, calcitonin, magnesium and bicarbonate. It is concluded that 3 g/day CaCO3 is equivalent to 2 g/day Al(OH)3 in terms of its phosphate-binding effect, and the prescription of CaCO3 together with 1 alpha (OH)D3 ameliorates secondary hyperparathyroidism.
AuthorsK Okada, S Takahashi, Y Nagura, M Hatano
JournalNihon Jinzo Gakkai shi (Nihon Jinzo Gakkai Shi) Vol. 31 Issue 10 Pg. 1085-9 (Oct 1989) ISSN: 0385-2385 [Print] JAPAN
PMID2615019 (Publication Type: Journal Article)
Chemical References
  • Aluminum Hydroxide
  • Calcium Carbonate
  • Adult
  • Aged
  • Aluminum Hydroxide (therapeutic use)
  • Calcium Carbonate (therapeutic use)
  • Female
  • Humans
  • Hyperparathyroidism, Secondary (drug therapy, etiology)
  • Male
  • Middle Aged
  • Renal Dialysis (adverse effects)

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