Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis.
Abstract | BACKGROUND: METHODS: Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. RESULTS: The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6 % versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HRadj = 1.35; 95 % CI = 1.05-1.73), but the association weakened after 10 years (HRadj = 1.13; 95 % CI = 0.91-1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HRadj = 1.70; 95 % CI = 1.17-2.45). CONCLUSIONS: ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases.
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Authors | Marcelo Sobral-Leite, Jelle Wesseling, Vincent T H B M Smit, Heli Nevanlinna, Martine H van Miltenburg, Joyce Sanders, Ingrid Hofland, Fiona M Blows, Penny Coulson, Gazinska Patrycja, Jan H M Schellens, Rainer Fagerholm, Päivi Heikkilä, Kristiina Aittomäki, Carl Blomqvist, Elena Provenzano, Hamid Raza Ali, Jonine Figueroa, Mark Sherman, Jolanta Lissowska, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Kelly-Anne Phillips, kConFab/AOCS Investigators, Fergus J Couch, Janet E Olson, Celine Vachon, Daniel Visscher, Hermann Brenner, Katja Butterbach, Volker Arndt, Bernd Holleczek, Maartje J Hooning, Antoinette Hollestelle, John W M Martens, Carolien H M van Deurzen, Bob van de Water, Annegien Broeks, Jenny Chang-Claude, Georgia Chenevix-Trench, Douglas F Easton, Paul D P Pharoah, Montserrat García-Closas, Marjo de Graauw, Marjanka K Schmidt |
Journal | BMC medicine
(BMC Med)
Vol. 13
Pg. 156
(Jul 02 2015)
ISSN: 1741-7015 [Electronic] England |
PMID | 26137966
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Annexin A1
- Biomarkers, Tumor
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Topics |
- Adult
- Annexin A1
(genetics)
- Biomarkers, Tumor
(genetics)
- Breast Neoplasms
(diagnosis, genetics)
- Female
- Genes, BRCA1
(physiology)
- Genes, BRCA2
(physiology)
- Genetic Predisposition to Disease
- Humans
- Immunohistochemistry
- Middle Aged
- Mutation
- Prognosis
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