Pure
non-gestational choriocarcinoma is a primary germ cell
neoplasm that has been defined as a
tumor without other germ cell elements. The current study presents an extremely rare case of non-gestational pure
choriocarcinoma in a postmenarcheal young female and describes details of the
tumor, including the clinicopathological findings. The patient was a 10-year-old female who underwent
salpingo-oophorectomy. Histologically, the extensive hemorrhagic
tumor was composed of
choriocarcinoma without additional
germ cell tumor components. The
tumor cells were immunohistochemically positive for epithelial markers, including cytokeratins and epithelial membrane
antigens, and there was a positive cytoplasmic reaction for β-
human chorionic gonadotropin in the syncytiotrophoblasts. Furthermore, numerous
tumor cells were immunohistochemically positive for the β2-microglobulin antibody. The patient received adjuvant
cisplatin,
etoposide and
bleomycin chemotherapy, and is currently disease-free without evidence of recurrence or
metastasis subsequent to 62 months of follow-up.