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Curative Resection After Gemcitabine, Cisplatin and S-1 Chemotherapy for Initially Unresectable Biliary Duct Cancer: A Case Report.

Abstract
A 68-year-old woman was diagnosed with unresectable upper bile duct cancer with suspected invasion of the right hepatic artery and para-aortic lymph node metastasis (T4N3M0, stage IVb). She underwent plastic stent placement for obstructive jaundice and enrolled in our phase I study for unresectable biliary tract cancer consisting of cisplatin (25 mg/m(2) i.v. for 120 min) followed by gemcitabine (1,000 mg/m(2) i.v. for 30 min) on days 1 and 8, and oral S-1 on alternate days. After 8 courses of neoadjuvant chemotherapy without adverse effects, computed tomography showed near-complete disappearance of the tumor of the upper bile duct and of swollen lymph nodes. She then underwent sub-total stomach-preserving pancreatico duodenectomy and lymph node dissection. The pathological stage was pT1N0M0, stage I. The patient made a satisfactory recovery, was discharged 29 days after operation, and remains free of disease at 3 months after the operation under adjuvant chemotherapy using S-1.
AuthorsKenei Furukawa, Tadashi Uwagawa, Taro Sakamoto, Hiroaki Shiba, Jun Tsutsumi, Katsuhiko Yanaga
JournalAnticancer research (Anticancer Res) Vol. 35 Issue 7 Pg. 4203-6 (Jul 2015) ISSN: 1791-7530 [Electronic] Greece
PMID26124379 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
Chemical References
  • Drug Combinations
  • Deoxycytidine
  • S 1 (combination)
  • Tegafur
  • Oxonic Acid
  • Cisplatin
  • Gemcitabine
Topics
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Biliary Tract Neoplasms (drug therapy, surgery)
  • Chemotherapy, Adjuvant (methods)
  • Cisplatin (administration & dosage)
  • Clinical Trials, Phase I as Topic
  • Deoxycytidine (administration & dosage, analogs & derivatives)
  • Drug Combinations
  • Female
  • Humans
  • Neoadjuvant Therapy (methods)
  • Oxonic Acid (administration & dosage)
  • Tegafur (administration & dosage)
  • Gemcitabine

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