Abstract |
A 68-year-old woman was diagnosed with unresectable upper bile duct cancer with suspected invasion of the right hepatic artery and para-aortic lymph node metastasis (T4N3M0, stage IVb). She underwent plastic stent placement for obstructive jaundice and enrolled in our phase I study for unresectable biliary tract cancer consisting of cisplatin (25 mg/m(2) i.v. for 120 min) followed by gemcitabine (1,000 mg/m(2) i.v. for 30 min) on days 1 and 8, and oral S-1 on alternate days. After 8 courses of neoadjuvant chemotherapy without adverse effects, computed tomography showed near-complete disappearance of the tumor of the upper bile duct and of swollen lymph nodes. She then underwent sub-total stomach-preserving pancreatico duodenectomy and lymph node dissection. The pathological stage was pT1N0M0, stage I. The patient made a satisfactory recovery, was discharged 29 days after operation, and remains free of disease at 3 months after the operation under adjuvant chemotherapy using S-1.
|
Authors | Kenei Furukawa, Tadashi Uwagawa, Taro Sakamoto, Hiroaki Shiba, Jun Tsutsumi, Katsuhiko Yanaga |
Journal | Anticancer research
(Anticancer Res)
Vol. 35
Issue 7
Pg. 4203-6
(Jul 2015)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 26124379
(Publication Type: Case Reports, Journal Article)
|
Copyright | Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
Chemical References |
- Drug Combinations
- Deoxycytidine
- S 1 (combination)
- Tegafur
- Oxonic Acid
- Cisplatin
- Gemcitabine
|
Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Biliary Tract Neoplasms
(drug therapy, surgery)
- Chemotherapy, Adjuvant
(methods)
- Cisplatin
(administration & dosage)
- Clinical Trials, Phase I as Topic
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Drug Combinations
- Female
- Humans
- Neoadjuvant Therapy
(methods)
- Oxonic Acid
(administration & dosage)
- Tegafur
(administration & dosage)
- Gemcitabine
|