Obstructive Jaundice (Cholestatic Jaundice)

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2081 relevant articles (84 outcomes, 205 trials/studies) found for this Disease

Description: JAUNDICE, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.

Also Known As:

Cholestatic Jaundice; Jaundice, Obstructive; Mechanical Jaundice; Jaundice, Cholestatic; Jaundice, Mechanical

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Hyperbilirubinemia: 2119

Jaundice: 4882

Obstructive Jaundice: 2081

Signs and Symptoms

Skin Manifestations: 311

Jaundice: 4882

Obstructive Jaundice: 2081

Related Diseases

1.	Jaundice
2.	Neoplasms (Cancer)
3.	Stomach Neoplasms (Stomach Cancer)
4.	Endotoxemia
5.	Pathologic Constriction (Stenosis)

Experts

1.	Assimakopoulos, Stelios F: 6 articles (06/2008 - 05/2004)
2.	Vagianos, Constantine E: 6 articles (01/2008 - 05/2004)
3.	Scopa, Chrisoula D: 5 articles (06/2006 - 05/2004)
4.	Georgiou, Christos: 4 articles (06/2008 - 05/2004)
5.	Padillo, Francisco J: 3 articles (07/2008 - 11/2002)
6.	Padillo, F J: 3 articles (10/2007 - 03/2001)
7.	Spiliopoulou, Iris: 3 articles (06/2006 - 05/2004)
8.	Nikolopoulou, Vassiliki N: 3 articles (06/2006 - 07/2005)
9.	Dirlik, Musa: 3 articles (05/2006 - 10/2002)
10.	Pata, Cengiz: 3 articles (05/2006 - 10/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Obstructive Jaundice:

1.	BilirubinIBA 03/01/1989 - "It was found that: (1) liver functions in the patients with obstructive jaundice were injured severely; bilirubin, R15ICG, m-GOT, and gamma-GT were increased significantly; (2) in patients with incomplete biliary obstruction or after the relief of obstruction, liver functions could be improved gradually. " 12/01/1996 - "The aim was to examine if delta-bilirubin reflects the duration of obstructive jaundice and efficacy of biliary drainage. " 03/01/2001 - "BACKGROUND: The present experimental study was carried out to determine variations in bilirubin and lipid metabolism in obstructive jaundice after external biliary drainage alone and in combination with intraintestinal administration of the drained bile. " 03/01/2001 - "Experimental study on lipid and bilirubin metabolism after biliary drainage for obstructive jaundice." 09/01/1997 - "METHODS: From September 1993 to December 1994, patients admitted with severe obstructive jaundice (serum bilirubin > 15 mg/dl) and successful drainage were enrolled into our study. " Order ALL the reference details at left...
2.	perfluoro- 2,2,2',2'- tetramethyl- 4,4'- bis(1,3- dioxolane)IBA 03/01/2008 - "Percutaneous biliary drainage and stenting (PTBD) for palliation of malignant obstructive jaundice has evolved to a safe and effective technique. " 11/01/2007 - "METHODS: Thirty-six patients with obstructive jaundice underwent the rendezvous technique of PTBD and ERCP after initially unsuccessful ERCP. " 01/01/2007 - "Percutaneous transhepatic biliary drainage (PTBD) with multiple drains was previously the preferred method for the preoperative relief of obstructive jaundice. " 09/01/2002 - "Percutaneous transhepatic biliary drainage (PTBD) is a well established method in the treatment of obstructive jaundice. " 06/01/2002 - "We conclude that PTBD is a safe modality and that it can be used in children for the relief of obstructive jaundice." Order ALL the reference details at left...
3.	CytokinesIBA 05/01/1999 - "CONCLUSION: These data demonstrate simultaneous impairment of Kupffer cell clearance of endotoxin and increased secretion of proinflammatory cytokines in experimental obstructive jaundice. " 05/01/1999 - "Kupffer cell clearance of endotoxin and secretion of cytokines in experimental obstructive jaundice were investigated. " 10/01/2001 - "Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB." 05/01/2000 - "CONCLUSIONS: The effects of obstructive jaundice in humans on endotoxin and cytokines are different from those in animal models. " 01/01/1996 - "We conclude that the production of some cytokines by monocytes is up-regulated in patients with obstructive jaundice." Order ALL the reference details at left...
4.	Glucose (Dextrose)FDA LinkGeneric 07/01/1999 - "This study was performed to investigate the concept of energy mediated by glucose, during the process of obstructive jaundice and its recovery. " 01/01/2002 - "The effects of obstructive jaundice on muscle glucose metabolism and expression of UCP2 in liver and muscle are unknown. " 01/01/2002 - "Obstructive jaundice results in increased liver expression of uncoupling protein 2 and intact skeletal muscle glucose metabolism in the rat." 03/01/1995 - "PURPOSE: Hepatic mitochondrial response to oral glucose load (redox tolerance test) was evaluated as an indicator of hepatic functional reserve of patients with obstructive jaundice. " 04/01/1980 - "[Glucose metabolism on intravenous glucose tolerance test in obstructive jaundice (author's transl)]" Order ALL the reference details at left...
5.	gemcitabine FDA Link 07/01/2008 - "CONCLUSION: Gemcitabine didn't show to improve survival and QoL in patients with advanced PC previously treated with a covered metallic biliary endoprosthesis due to obstructive jaundice." 07/01/2008 - "PATIENTS AND METHODS: Forty-nine patients with unresectable PC and obstructive jaundice, previously treated with the placement of a covered metal biliary endoprosthesis, were randomized to receive gemcitabine (group A: 9 males, 7 females) or to be followed without any anticancer intervention (group B: 18 males, 15 females). " 06/01/2009 - "Immediately after relief from obstructive jaundice, combination chemotherapy of S-1 and gemcitabine was given. " 08/01/2008 - "Gemcitabine therapy after endoscopic intervention was safe and effective in this case of recurrent gall bladder cancer with obstructive jaundice." 12/01/2003 - "Since obstructive jaundice had progressed rapidly, the patient received endoscopic nasobiliary drainage (ENBD) and stent-drainage therapy prior to chemotherapy using gemcitabine. " Order ALL the reference details at left...
6.	titanium silicide (TS-1)IBA 05/01/2006 - "TS-1 chemotherapy was continued afterwards, however obstructive jaundice was found. " 09/01/2002 - "We report 3 cases in which palliation was achieved with every-other-day administration of TS-1 for recurrent or non-curative advanced gastric carcinoma that had resulted in obstructive jaundice. " 03/01/2003 - "In conclusion, the placement of a self-expandable metallic stent in combination with cholangioscopic microwave coagulation therapy and TS-1 was very effective in managing the obstructive jaundice due to the local recurrence of gastric cancer." 10/01/2001 - "In conclusion, TS-1 may be well-tolerable and effective in some cases of terminal-stage and/or recurrent gastric cancer, especially those associated with obstructive jaundice arising from the cancerous lymphadenopathy, in that patient QOL can be maintained to a much greater extent." 03/01/2003 - "A self-expandable metallic stent in combination with cholangioscopic microwave coagulation therapy and chemotherapy with oral TS-1 against obstructive jaundice due to recurrent gastric cancer: a case report of successful treatment." Order ALL the reference details at left...
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2009 - "PURPOSE: we aim to explore the protective effects of Salvia miltiorrhizae injection on multiple organs of obstructive jaundice (OJ) rats through observing the impact of this injection on the pathological alterations in these organs and the contents of endotoxin, PLA(2), and TNF-alpha in the blood. " 10/01/2007 - "Several experimental studies of obstructive jaundice (OJ) have shown the presence of immunosuppressive state associated with the rise of tumor necrosis factor-alpha (TNF-alpha) concentration in plasma. " 10/01/2007 - "Anti-TNF-alpha treatment and bile duct drainage restore cellular immunity and prevent tissue injury in experimental obstructive jaundice." 08/01/2003 - "OBJECTIVE: To assess the influence of different drainage procedures on the levels of serum endotoxin and tumor necrosis factor (TNF) in patients with malignant obstructive jaundice (MOJ). " 08/01/2003 - "Effects of different drainage procedures on levels of serum endotoxin and tumor necrosis factor in patients with malignant obstructive jaundice." Order ALL the reference details at left...
8.	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 09/01/1997 - "BACKGROUND: The aim of this study is to evaluate the therapeutic effect of ursodeoxycholic acid (UDCA) for patients with severe obstructive jaundice after drainage procedure. " 09/01/1997 - "The effects of ursodeoxycholic acid in patients with severe obstructive jaundice after drainage procedure." 09/01/1997 - "OBJECTIVE: To describe two infants with cholestatic jaundice treated with ursodeoxycholic acid (UDCA). " 01/01/1995 - "Effects of ursodeoxycholic acid on hemodynamic and renal function abnormalities induced by obstructive jaundice in rats." 08/01/1986 - "A randomized clinical trial of oral ursodeoxycholic acid in obstructive jaundice." Order ALL the reference details at left...
9.	EnzymesIBA 01/01/1968 - "Studies on the activity of so-called excretory enzymes in experimental obstructive jaundice in rabbits. " 01/01/1968 - "Studies on the activity of so-called excretory enzymes in experimental obstructive jaundice in rabbits. " 04/01/1991 - "Mechanism of adaptive increase of respiratory enzymes in rat liver mitochondria during obstructive jaundice." 10/01/1988 - "In patients with obstructive jaundice the activity of the fibrinolytic enzymes was usually normal, rarely increased. " 01/01/1985 - "Are urinary enzymes useful markers of kidney damage in obstructive jaundice? " Order ALL the reference details at left...
10.	Glutamine (L-Glutamine)FDA Link 10/01/2005 - "Administration of glutamine has been proposed to maintain the integrity of the gut mucosa and thus reduce bacterial translocation (BT), but the effects of this pretreatment on apoptosis and histologic morphology of various organs affected by BT in obstructive jaundice have not been studied. " 07/01/2005 - "Beneficial effects of glutamine on intestinal barrier function in obstructive jaundice." 10/01/2004 - "We hypothesize that obstructive jaundice may alter serum TGFbeta1 and MCP-1 expressions in the rat and that oral bile acid or glutamine (or both) can restore the altered serum TGFbeta1 and MCP-1 expression in rats with obstructive jaundice. " 01/01/2002 - "Oral glutamine intake daily could effectively restore the CD44 expression in the small intestine of the rat undergoing obstructive jaundice for 2 weeks." 01/01/2002 - "We hypothesize that obstructive jaundice may alter CD44 expression in the rat small intestine and oral glutamine intake can restore the altered CD44 expression in the small intestine of the rat undergoing obstructive jaundice. " Order ALL the reference details at left...

Therapies and Procedures

1.	Stents 04/01/1990 - "The expandable metallic stent could be used for the effective treatment of obstructive jaundice." 05/01/1996 - "PURPOSE: The aim of this study was to analyze the clinical efficacy of metal stents in the palliation of malignant obstructive jaundice. " 11/25/1992 - "[Efficacy of biliary endoprostheses using expandable metallic stents in obstructive jaundice--long-term results of three different types of stent]" 07/11/1987 - "Randomised trial of endoscopic versus percutaneous stent insertion in malignant obstructive jaundice." 06/01/2009 - "To reduce the degree of obstructive jaundice, a self-expandable metallic stent was placed in the area of the biliary obstruction. " Order ALL the reference details at left...
2.	Decompression 03/01/1977 - "This simple technique is found to be useful in the management of obstructive jaundice not only for preoperative decompression of biliary tree but also for the inoperable lesions." 04/01/1989 - "This study compares the efficacy of percutaneous transhepatic drainage (PTD) versus operative biliary decompression for patients with malignant obstructive jaundice. " 06/01/1984 - "Efficacy of preoperative biliary tract decompression in patients with obstructive jaundice." 06/01/2009 - "BACKGROUND AND STUDY AIMS: Endoscopic retrograde cholangiography (ERC) with stenting is the procedure of choice for biliary decompression in patients with obstructive jaundice. " 04/01/2008 - "Endoscopic retrograde cholangio pancreatography (ERCP) is the procedure of choice for biliary decompression in individuals with obstructive jaundice. " Order ALL the reference details at left...
3.	Hepatectomy 03/01/1994 - "We studied 11C-MET-PET in 17 clinical cases, 10 patients with obstructive jaundice and 7 normal volunteers, and analyzed its efficacy for the evaluation of hepatic functional reserve in major hepatectomy candidates. " 10/01/2000 - "After preoperative percutaneous biliary drainage in obstructive jaundice, attempts have been made to reduce the volume of blood loss even in extensive hepatectomy, the extent of liver resection in poor risk cases has been reduced without sacrificing radicality, and, by minimizing surgical stress, perioperative management has been greatly improved." 04/07/2006 - "AIM: To study the effects of obstructive jaundice on liver regeneration after partial hepatectomy. " 01/01/2001 - "The aim of this study was to examine whether the transcription of IEGs was induced by obstructive jaundice during liver regeneration after 70% partial hepatectomy, and to examine their association with animal survival, cell proliferation, and apoptosis. " 04/08/2008 - "OBJECTIVE: To investigate the impact of obstructive jaundice on hepatectomy. " Order ALL the reference details at left...
4.	Cholecystectomy 01/01/2005 - "A 24-year-old lady presented with bilious expectoration and history suggestive of obstructive jaundice, 16 months following open cholecystectomy. " 03/01/2004 - "[Obstructive jaundice after cholecystectomy]" 10/01/2001 - "In 298 patients with obstructive jaundice, including 271 (90.9%) with tumoral genesis, endobiliary interventions were performed: transcutaneous transhepatic cholecystectomy--in 76, external cholangiostomy--in 155, external-internal cholangiostomy--in 97, endoprosthesis of biliary ducts (BD)--in 23. " 11/01/2000 - "We present the case of an elderly and frail woman, admitted for obstructive jaundice 9 years after cholecystectomy, lithotomy and T-tube drainage. " 06/01/1999 - "A 70-year-old man with previous cholecystectomy developed progressive obstructive jaundice, 3 months before hospitalization. " Order ALL the reference details at left...
5.	Parenteral Nutrition 05/01/1982 - "The cholestatic jaundice improved with the return to normal of liver function when the lipid emulsion dosage was reduced or intravenous feeding was discontinued." 12/08/1978 - "After parenteral nutrition had been discontinued obstructive jaundice cleared by the third month of life except in one infant. " 05/01/1980 - "Prospective controlled study of parenteral nutrition-associated cholestatic jaundice: effect of protein intake." 04/01/1995 - "Metabolic effect of parenteral nutrition in dogs with obstructive jaundice." 03/01/1987 - "A case is presented of a very preterm neonate who developed severe cholestatic jaundice in association with prolonged parenteral nutrition. " Order ALL the reference details at left...

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