SIRT1 as a Promising Novel Therapeutic Target for Myocardial Ischemia Reperfusion Injury and Cardiometabolic Disease.

Abstract

BACKGROUND:

Cardiovascular diseases, especially ischemic heart disease and cardiometabolic disease, remain to be the leading cause of morbidity and mortality worldwide. Despite recent progress in diagnostic and therapeutic approaches, the incidence of cardiovascular disease is still rising. Therefore, alternative favorable treatment is urgently needed to rescue the fast growing numbers of patients.

OBJECTIVE:

Herein we aimed to review the relevant role and explore the possibility of SIRT1 as a promising target for protection of heart from ischemia/reperfusion injury and cardiometabolic diseases.

RESULTS:

The activation of SIRT1 participates in a variety of important metabolic and physiologic processes including stress resistance, metabolism, apoptosis and energy balance in heart ischemia injury and cardiometabolic disease.

CONCLUSION:

Current medication targeting SIRT1 may represent a new therapeutic trend for the prevention of cardiovascular disease that is related to energy balance and metabolism.

• Authors: Dong Han, Jinda Wang, Sai Ma, Yundai Chen, Feng Cao
• Journal: Current drug targets (Curr Drug Targets) Vol. 18 Issue 15 Pg. 1746-1753 ( 2017) ISSN: 1873-5592 [Electronic] United Arab Emirates
• PMID: 26122034 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Heterocyclic Compounds, 4 or More Rings
• SRT1720
• Stilbenes
• SIRT1 protein, human
• Sirtuin 1
• Resveratrol

Topics

• Animals
• Apoptosis
• Disease Models, Animal
• Heterocyclic Compounds, 4 or More Rings (pharmacology, therapeutic use)
• Humans
• Metabolic Diseases (drug therapy, metabolism)
• Molecular Targeted Therapy
• Myocardial Ischemia (drug therapy, metabolism)
• Myocardial Reperfusion Injury (drug therapy, metabolism)
• Myocytes, Cardiac (cytology)
• Resveratrol
• Sirtuin 1 (metabolism)
• Stilbenes (pharmacology, therapeutic use)
• Transcriptional Activation (drug effects)