Abstract | OBJECTIVES: MATERIAL AND METHODS: Rats were randomly divided into four groups, namely Group I (control rats), Group II ( ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores. RESULTS: Following the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit scores of p-coumaric acid-treated rats were significantly improved after cerebral ischemia. CONCLUSION:
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Authors | Mustafa Guven, Adem Bozkurt Aras, Tarik Akman, Halil Murat Sen, Adile Ozkan, Osman Salis, Ibrahim Sehitoglu, Yildiray Kalkan, Coskun Silan, Mustafa Deniz, Murat Cosar |
Journal | Iranian journal of basic medical sciences
(Iran J Basic Med Sci)
Vol. 18
Issue 4
Pg. 356-63
(Apr 2015)
ISSN: 2008-3866 [Print] Iran |
PMID | 26019798
(Publication Type: Journal Article)
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