Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women.

Abstract

The lemon detox program is a very low-calorie diet which consists of a mixture of organic maple and palm syrups, and lemon juice for abstinence period of 7 days. We hypothesized that the lemon detox program would reduce body weight, body fat mass, thus lowering insulin resistance and known risk factors of cardiovascular disease. We investigated anthropometric indices, insulin sensitivity, levels of serum adipokines, and inflammatory markers in overweight Korean women before and after clinical intervention trial. Eighty-four premenopausal women were randomly divided into 3 groups: a control group without diet restriction (Normal-C), a pair-fed placebo diet group (Positive-C), and a lemon detox diet group (Lemon-D). The intervention period was 11 days total: 7 days with the lemon detox juice or the placebo juice, and then 4 days with transitioning food. Changes in body weight, body mass index, percentage body fat, and waist-hip ratio were significantly greater in the Lemon-D and Positive-C groups compared to the Normal-C group. Serum insulin level, homeostasis model assessment insulin resistance scores, leptin, and adiponectin levels decreased in the Lemon-D and Positive-C groups. Serum high-sensitive C-reactive protein (hs-CRP) levels were also reduced only in the Lemon-D group. Hemoglobin and hematocrit levels remained stable in the Lemon-D group while they decreased in the Positive-C and Normal-C groups. Therefore, we suppose that the lemon detox program reduces body fat and insulin resistance through caloric restriction and might have a potential beneficial effect on risk factors for cardiovascular disease related to circulating hs-CRP reduction without hematological changes.

• Authors: Mi Joung Kim, Jung Hyun Hwang, Hyun Ji Ko, Hye Bock Na, Jung Hee Kim
• Journal: Nutrition research (New York, N.Y.) (Nutr Res) Vol. 35 Issue 5 Pg. 409-20 (May 2015) ISSN: 1879-0739 [Electronic] United States
• PMID: 25912765 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• C-Reactive Protein

Topics

• Acer (chemistry)
• Adiposity
• Adult
• Arecaceae (chemistry)
• Beverages
• Body Mass Index
• C-Reactive Protein (analysis)
• Caloric Restriction (adverse effects)
• Cardiovascular Diseases (epidemiology, etiology, prevention & control)
• Citrus (chemistry)
• Diet Fads (adverse effects)
• Double-Blind Method
• Down-Regulation
• Female
• Hematologic Tests
• Humans
• Insulin Resistance
• Overweight (diet therapy, immunology, metabolism, physiopathology)
• Republic of Korea (epidemiology)
• Risk Factors
• Sorption Detoxification (adverse effects)
• Weight Loss