Abstract | BACKGROUND: OBJECTIVE: MATERIALS AND METHODS: Precision cut rat liver slices were treated with benzo[a]pyrene at 1 and 5 μM in the presence of PEITC (1-25 μM) for 24 hours, followed by determination of CYP1A1 mRNA and apoprotein levels using quantitative polymerase chain reaction and immunoblotting. RESULTS: CONCLUSIONS: It was demonstrated that PEITC can directly inhibit the bioactivation of benzo[a]pyrene, indicating chemopreventive potential.
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Authors | Ahmad Faizal Abdull Razis, Nattaya Konsue, Costas Ioannides |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 16
Issue 7
Pg. 2679-83
( 2015)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 25854346
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticarcinogenic Agents
- Apoproteins
- Isothiocyanates
- Polycyclic Aromatic Hydrocarbons
- RNA, Messenger
- Benzo(a)pyrene
- phenethyl isothiocyanate
- Cytochrome P-450 CYP1A1
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Topics |
- Animals
- Anticarcinogenic Agents
(pharmacology)
- Apoproteins
(metabolism)
- Benzo(a)pyrene
(pharmacology)
- Cell Transformation, Neoplastic
(drug effects)
- Chemoprevention
(methods)
- Cytochrome P-450 CYP1A1
(genetics, metabolism)
- Isothiocyanates
(pharmacology)
- Liver
(enzymology)
- Male
- Polycyclic Aromatic Hydrocarbons
(metabolism)
- RNA, Messenger
(genetics)
- Rats
- Rats, Wistar
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