Contactin 1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia.

Abstract	A Spanish group recently reported that four patients with chronic inflammatory demyelinating polyneuropathy carrying IgG4 autoantibodies against contactin 1 showed aggressive symptom onset and poor response to intravenous immunoglobulin. We aimed to describe the clinical and serological features of Japanese chronic inflammatory demyelinating polyneuropathy patients displaying the anti-contactin 1 antibodies. Thirteen of 533 (2.4%) patients with chronic inflammatory demyelinating polyneuropathy had anti-contactin 1 IgG4 whereas neither patients from disease or normal control subjects did (P = 0.02). Three of 13 (23%) patients showed subacute symptom onset, but all of the patients presented with sensory ataxia. Six of 10 (60%) anti-contactin 1 antibody-positive patients had poor response to intravenous immunoglobulin, whereas 8 of 11 (73%) antibody-positive patients had good response to corticosteroids. Anti-contactin 1 IgG4 antibodies are a possible biomarker to guide treatment option.
Authors	Yumako Miura, Jérôme J Devaux, Yuki Fukami, Constance Manso, Maya Belghazi, Anna Hiu Yi Wong, Nobuhiro Yuki, CNTN1-CIDP Study Group
Journal	Brain : a journal of neurology (Brain) Vol. 138 Issue Pt 6 Pg. 1484-91 (Jun 2015) ISSN: 1460-2156 [Electronic] England
PMID	25808373 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	© The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: [email protected].
Chemical References	Adrenal Cortex Hormones Autoantibodies Biomarkers, Pharmacological Contactin 1 Epitopes Immunoglobulin G Immunoglobulins, Intravenous
Topics	Adrenal Cortex Hormones (therapeutic use) Adult Aged Aged, 80 and over Ataxia (blood, complications, drug therapy, immunology) Autoantibodies (blood, immunology) Biomarkers, Pharmacological (blood) Case-Control Studies Cells, Cultured Contactin 1 (immunology, metabolism) Epitopes (immunology) Female Ganglia, Spinal (metabolism) Humans Immunoglobulin G (blood, immunology) Immunoglobulins, Intravenous (therapeutic use) Male Middle Aged Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (blood, complications, drug therapy, immunology) Retrospective Studies

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