Abstract | AIM: PATIENTS AND METHODS: We retrospectively analyzed 140 patients with the following criteria: (a) positive bone lesions identified with C- choline PET/CT and validated as true positive by histology (14.2%), correlative imaging (33.4%), or clinical follow-up (52.4%); (b) after radical prostatectomy (67.9%) or primary radiotherapy (22.1%); (c) proven biochemical relapse with rising PSA levels; (d) no chemotherapy, zoledronic acid, or palliative bone external beam radiation therapy previously administrated during biochemical relapse; and (f) asymptomatic for bone pain. Lesions were categorized as osteoblastic, osteolytic, or bone marrow lesions. Patients were divided into osteoblastic and osteolytic patient groups. RESULTS: C- Choline PET/CT detected oligometastatic bone disease (1-3 lesions) in 98 (70%) of the 140 patients and multiple bone lesions in 42 (30%) of the 140 patients. By per-lesion analysis of 304 lesions, there were 184 osteoblastic, 99 osteolytic, and 21 bone marrow lesions.By per-patient analysis, 97 (69.3%) of the 140 patients were in the osteoblastic group, whereas 43 (30.7%) of the 140 patients were in the osteolytic group. Statistically significant differences in SUVmax (P < 0.001), fast PSA doubling time (P = 0.01), and PSA velocity (P = 0.01) were observed between osteoblastic (lower values) and osteolytic (higher values) groups. By multivariate analysis, fast PSA doubling time was a significant predictor for osteolytic lesions. CONCLUSIONS: We demonstrated differences in PSA kinetics and SUVmax between osteolytic and osteoblastic lesions. C- Choline PET/CT may identify patients that could benefit from early targeted therapies, depending on the type of bone lesions expressed.
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Authors | Francesco Ceci, Paolo Castellucci, Tiziano Graziani, Riccardo Schiavina, Sotirios Chondrogiannis, Rachele Bonfiglioli, Stefano Costa, Irene J Virgolini, Domenico Rubello, Stefano Fanti, Patrick M Colletti |
Journal | Clinical nuclear medicine
(Clin Nucl Med)
Vol. 40
Issue 5
Pg. e265-70
(May 2015)
ISSN: 1536-0229 [Electronic] United States |
PMID | 25783519
(Publication Type: Journal Article)
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Chemical References |
- Carbon Radioisotopes
- Radiopharmaceuticals
- Choline
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Topics |
- Aged
- Aged, 80 and over
- Bone Neoplasms
(diagnostic imaging, secondary)
- Carbon Radioisotopes
- Choline
- Humans
- Male
- Middle Aged
- Multimodal Imaging
- Positron-Emission Tomography
- Prostatic Neoplasms
(diagnostic imaging, pathology)
- Radiopharmaceuticals
- Tomography, X-Ray Computed
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