Enprostil reduces the increase of gastric corpus mucosal mass induced by the hydrogen-potassium-stimulated adenosine triphosphatase inhibitor BY 831-78 in the rat.

Abstract

We studied whether enprostil, a synthetic prostaglandin E2 derivative, might inhibit gastrin release and the trophic effects on gastric oxyntic mucosa induced by prolonged treatment with an inhibitor of hydrogen-potassium-stimulated adenosine triphosphatase, the substituted benzimidazole BY 831-78. Rats were treated intragastrically with enprostil (1 or 15 micrograms/kg b.i.d.), BY 831-78 (15 mumol/kg once daily), the combination of enprostil and BY 831-78, ranitidine (300 mumol/kg b.i.d.), and placebo. Plasma gastrin and somatostatin levels and gastric acid secretion were measured during a 1-day treatment in animals fitted with chronic gastric fistulas and repeatedly during 9 wk of treatment in intact rats. Despite inhibiting acid secretion, enprostil did not increase plasma gastrin. When combined with BY 831-78, enprostil transiently reduced the BY 831-78-induced increase of integrated plasma gastrin (1375 +/- 206 vs. 2137 +/- 256 pmol/L.12 h, p less than 0.05) in fasted rats with fistulas, but failed to prevent the marked hypergastrinemia following 9 wk of treatment with BY 831-78 (717 +/- 80 vs. 731 +/- 56 pmol/L) in intact rats. However, enprostil reduced the BY 831-78-induced increase of oxyntic mucosal volume (458 +/- 31 vs. 567 +/- 33 mm3, p less than 0.01), whereas BY 831-78 prevented the enprostil-induced increase of antral mucosal volume (42 +/- 3 vs. 56 +/- 3 mm3, p less than 0.01). These results demonstrate that some of the trophic effects induced by a hydrogen-potassium-stimulated adenosine triphosphatase inhibitor are not exclusively governed by gastrin.

• Authors: W Inauen, C Rohner, H R Koelz, J Herdmann, C C Schürer-Maly, L Varga, F Halter
• Journal: Gastroenterology (Gastroenterology) Vol. 97 Issue 4 Pg. 846-52 (Oct 1989) ISSN: 0016-5085 [Print] United States
• PMID: 2570729 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzimidazoles
• Gastrins
• Prostaglandins E, Synthetic
• BY 831-78
• Somatostatin
• Adenosine Triphosphatases
• H(+)-K(+)-Exchanging ATPase
• Enprostil

Topics

• Adenosine Triphosphatases (antagonists & inhibitors, pharmacology)
• Animals
• Benzimidazoles
• Enprostil
• Female
• Gastric Acid (metabolism)
• Gastric Mucosa (cytology, drug effects)
• Gastrins (blood)
• H(+)-K(+)-Exchanging ATPase
• Hydrogen-Ion Concentration
• Prostaglandins E, Synthetic (pharmacology)
• Rats
• Rats, Inbred Strains
• Somatostatin (blood)