Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life.

Abstract

The 2015 Paediatric European Network for Treatment of AIDS (PENTA) guidelines provide practical recommendations on the management of HIV-1 infection in children in Europe and are an update to those published in 2009. Aims of treatment have progressed significantly over the last decade, moving far beyond limitation of short-term morbidity and mortality to optimizing health status for adult life and minimizing the impact of chronic HIV infection on immune system development and health in general. Additionally, there is a greater need for increased awareness and minimization of long-term drug toxicity. The main updates to the previous guidelines include: an increase in the number of indications for antiretroviral therapy (ART) at all ages (higher CD4 thresholds for consideration of ART initiation and additional clinical indications), revised guidance on first- and second-line ART recommendations, including more recently available drug classes, expanded guidance on management of coinfections (including tuberculosis, hepatitis B and hepatitis C) and additional emphasis on the needs of adolescents as they approach transition to adult services. There is a new section on the current ART 'pipeline' of drug development, a comprehensive summary table of currently recommended ART with dosing recommendations. Differences between PENTA and current US and World Health Organization guidelines are highlighted and explained.

• Authors: A Bamford, A Turkova, H Lyall, C Foster, N Klein, D Bastiaans, D Burger, S Bernadi, K Butler, E Chiappini, P Clayden, M Della Negra, V Giacomet, C Giaquinto, D Gibb, L Galli, M Hainaut, M Koros, L Marques, E Nastouli, T Niehues, A Noguera-Julian, P Rojo, C Rudin, H J Scherpbier, G Tudor-Williams, S B Welch, (PENTA Steering Committee)
• Journal: HIV medicine (HIV Med) Vol. 19 Issue 1 Pg. e1-e42 (01 2018) ISSN: 1468-1293 [Electronic] England
• PMID: 25649230 (Publication Type: Journal Article, Practice Guideline, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 British HIV Association.

Chemical References

• Anti-Retroviral Agents

Topics

• AIDS-Related Opportunistic Infections (drug therapy)
• Acquired Immunodeficiency Syndrome (complications, diagnosis, drug therapy)
• Adolescent
• Anti-Retroviral Agents (therapeutic use)
• Child
• Child, Preschool
• Coinfection (drug therapy)
• Europe
• Female
• Humans
• Infant
• Infant, Newborn
• Male