Abstract | OBJECTIVE: METHODS: Fifty nondiabetic patients with untreated mild hypertension were randomly assigned to telmisartan (40 mg/day) and valsartan (80 mg/day) groups and were switched in a crossover manner at 3-month intervals. Serum leptin, adiponectin, hsCRP and the HOMA-R were measured before and at 3 months during each treatment period. RESULTS: The HOMA-R significantly improved over the 3 months in the high insulin resistance group (HOMA-R>/=2.5) during the telmisartan treatment period (p=0.042), but not during the valsartan period. Both telmisartan and valsartan significantly decreased serum leptin levels in each female group during each treatment period (p<0.001 and p<0.001, respectively), but not in the male groups. Serum adiponectin did not increase in either treatment group. Serum hsCRP levels also significantly decreased in the high hsCRP subjects (>/=0.1) of both treatment groups (p=0.044 and p=0.015, respectively). CONCLUSIONS:
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Authors | Hiroyuki Ohbayashi, Shinya Minatoguchi, Takuma Aoyama, Hisayoshi Fujiwara |
Journal | Journal of rural medicine : JRM
(J Rural Med)
Vol. 5
Issue 2
Pg. 165-74
( 2010)
ISSN: 1880-487X [Print] Japan |
PMID | 25649195
(Publication Type: Journal Article)
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