Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.

Abstract

CONTEXT:

We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk.

OBJECTIVE:

The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT).

METHODS:

The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235).

RESULTS:

The area under the curve for ASSIST was greater than that of IL6 and PCT.

CONCLUSIONS:

ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.

• Authors: Hector R Wong, Keith R Walley, Ville Pettilä, Nuala J Meyer, James A Russell, Sari Karlsson, Michael G S Shashaty, Christopher J Lindsell
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 20 Issue 2 Pg. 132-5 (Mar 2015) ISSN: 1366-5804 [Electronic] England
• PMID: 25578228 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• CALCA protein, human
• Interleukin-6
• Protein Precursors
• Calcitonin
• Calcitonin Gene-Related Peptide

Topics

• Aged
• Biomarkers (blood)
• Calcitonin (blood)
• Calcitonin Gene-Related Peptide
• Cohort Studies
• Female
• Humans
• Interleukin-6 (blood)
• Male
• Middle Aged
• Prognosis
• Protein Precursors (blood)
• ROC Curve
• Reproducibility of Results
• Risk Assessment (methods)
• Risk Factors
• Sepsis (blood, diagnosis, mortality)
• Severity of Illness Index
• Shock, Septic (blood, diagnosis, mortality)
• Survival Analysis
• Survival Rate